Clopidogrel results in favourable changes in nitric oxide metabolism in patients undergoing percutaneous coronary intervention

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Author
Bundhoo, Shantu
Sagan, Ewelina
James, Philip
Anderson, Richard
Date
2017-11-27Acceptance date
2013-09-12
Type
Article
Publisher
Thieme
Metadata
Show full item recordAbstract
Clopidogrel has been shown to have a morbidity and mortality benefit in the prevention of ischaemic complications in patients with acute coronary syndrome and/or after percutaneous coronary intervention (PCI)1. 600mg of clopidogrel can not only significantly inhibit platelet inhibition acutely (within 2 hours) but also improve endothelial dysfunction in stable CAD patients via a mechanism independent of platelet function2. A reduction in endothelial injury after PCI also occurs in the presence of clopidogrel3. Clopidogrel has also been associated with improved systemic endothelial nitric oxide (NO) bioavailability in patients with coronary artery disease2. Endothelial nitric oxide synthase (eNOS) is the main source of NO in the vasculature4 and its activity directly proportional to plasma nitrite concentration and reflects cardiovascular NO bioavailability5. 70% of resting plasma nitrite is derived from eNOS activity in humans. NO metabolites including nitrite, nitrate and RSNO are now considered a direct measure of a physiological activity of NO and also a biologically active NO reservoir. We examined the effect of acute and chronic clopidogrel on these NO metabolites, the vasodilatory effect (cGMP) and oxidative/nitrosative stress markers in the plasma in patients undergoing PCI
Journal/conference proceeding
Thrombosis and Haemostasis;
Citation
Bundhoo, S., Sagan, E., James, P.E. and Anderson, R.A. (2014) 'Clopidogrel results in favourable changes in nitric oxide metabolism in patients undergoing percutaneous coronary intervention', Thrombosis and haemostasis, 111(2), p.373
Description
Article published in Thrombosis and Haemostasis (as a letter to the editor) available at https://doi.org/10.1160/TH13-05-0394
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