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dc.contributor.authorTremblay, Joshua
dc.contributor.authorHoiland, Ryan
dc.contributor.authorCarter, Howard
dc.contributor.authorHowe, Connor
dc.contributor.authorStembridge, Mike
dc.contributor.authorWillie, Christopher
dc.contributor.authorGasho, Christopher
dc.contributor.authorMacLeod, David
dc.contributor.authorPyke, Kyra
dc.contributor.authorAinslie, Philip
dc.date.accessioned2018-09-19T15:37:22Z
dc.date.available2018-09-19T15:37:22Z
dc.date.issued2018-08-31
dc.identifier.citationTremblay, J.C., Hoiland, R.L., Carter, H.H., Howe, C.A., Stembridge, M., Willie, C.K., Gasho, C., Macleod, D.B., Pyke, K.E. and Ainslie, P.N. (2018) 'UBC-Nepal Expedition: Upper and Lower Limb Conduit Artery Shear Stress and Flow-Mediated Dilation on Ascent to 5050 m in Lowlanders and Sherpa', American Journal of Physiology-Heart and Circulatory Physiology - in pressen_US
dc.identifier.issn1522-1539 (ESSN)
dc.identifier.urihttp://hdl.handle.net/10369/10069
dc.descriptionArticle published in American Journal of Physiology - Heart and Circulatory Physiology on 31 August 2018 available at https://doi.org/10.1152/ajpheart.00345.2018en_US
dc.description.abstractThe study of conduit artery endothelial adaptation to hypoxia has been restricted to the brachial artery, and comparisons to highlanders have been confounded by differences in altitude exposure, exercise, and unknown levels of blood viscosity. To address these gaps, we tested the hypothesis that lowlanders, but not Sherpa, would demonstrate decreased mean shear stress and increased retrograde shear stress, and subsequently reduced flow-mediated dilation (FMD), in the upper and lower limb conduit arteries on ascent to 5050m. Healthy lowlanders (n=22, 28±6 years [mean±SD]) and Sherpa (n=12, 34±11 years) ascended over 10 days, with measurements taken on non-trekking days at 1400m (baseline), 3440m (day 4), 4371m (day 7), and 5050m (day 10). Arterial blood gases, blood viscosity, shear stress and FMD (duplex ultrasound of the brachial [BA] and superficial femoral [SFA] arteries) were acquired at each time-point. Ascent decreased mean and increased retrograde shear stress in the upper and lower limb of lowlanders and Sherpa. Although BA FMD decreased in the lowlanders from 7.1±3.9% to 3.8±2.8% at 5050m versus 1400m (P<0.001), SFA FMD was preserved. In the Sherpa, neither BA nor SFA FMD were changed upon ascent to 5050m. In lowlanders, the ascent-related exercise may favorably influence endothelial function in the active limb (SFA); selective impairment in FMD in the BA in lowlanders is likely mediated via the low mean or high oscillatory baseline shear stress. In contrast, Sherpa presented protected endothelial function, suggesting a potential vascular aspect of high-altitude acclimatization/adaptation.en_US
dc.language.isoenen_US
dc.publisherAmerican Physiological Societyen_US
dc.relation.ispartofseriesAmerican Journal of Physiology - Heart and Circulatory Physiology;
dc.titleUBC-Nepal Expedition: Upper and Lower Limb Conduit Artery Shear Stress and Flow-Mediated Dilation on Ascent to 5050 m in Lowlanders and Sherpaen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1152/ajpheart.00345.2018
dcterms.dateAccepted2018-08-27
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2018-09-19
rioxxterms.freetoread.startdate2019-08-31


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