Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers
MetadataShow full item record
The chemokine CCL11 has been implicated in age-related cognitive deterioration in mice, yet evidence on the relationship between CCL11 and cognitive function in humans is limited. This study explored associations between CCL11 and cognition in rural and urban community-dwelling older adults. Participants were 515 urban dwellers from the 3C-Bordeaux cohort and 318 rural dwellers from the AMI cohort. Plasma CCL11 was measured using an enzyme-linked immunoassay. Mini Mental State Examination (MMSE) test scores were used as the main measure of cognitive performance. Multivariate regression analysis was used to evaluate the cross-sectional association between CCL11 and cognitive performance. CCL11 was significantly higher in rural dwellers compared to city dwellers (median [IQR]: 145 [115–201] pg/mL vs. 103 [85–129] pg/mL; p < 0.001). After adjustment for confounders, CCL11 was found to be negatively associated with cognitive performance in rural dwellers but not in city dwellers. These results suggest that CCL11 may be an independent determinant of cognitive function in older rural dwellers and that the residential environment modifies this association.
Butcher, L., Peres, K., Morris, R., Walter, S., Dartigues, J-F., Rodriguez-Mañas, L., Feart, C. and Erusalimsky, J. (2018) 'Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers', Experimental Gerontology, Article in Press
Article published as accepted manuscript in Experimental Gerontology on 09 October 2018 available at https://doi.org/10.1016/j.exger.2018.10.004
Showing items related by title, author, subject and abstract.
Skillicorn, Deiniol (University of WalesCardiff School of Health Sciences, 2010)Executive cognitive processes and emotion cue processing was explored in introvertive anhedonia, the O-LIFE’s negative schizotypal trait dimension, with the aim of identifying endophenotypes. The experimental work of the ...
Orjiakor, Charles; Watt, Andrew; Iorfa, Steven; Onu, Desmond; Okonkwo, Angela (Elsevier, 2019-10-21)Schizophrenic symptoms have often been associated with antisocial behaviours (ASBs). Most studies have focused on violence. The association between schizophrenia and violence is often confounded by socio demographic ...
Price, Carwyn (University of Wales Institute Cardiff, 2008)The study aimed to investigate the health related fitness level and physical activity behaviour of urban and rural Welsh schoolboys. The sample comprised of 31 urban and 21 rural boys, all aged 11-12 yrs. The health related ...