• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers

Thumbnail
View/open
Author's post-print (968.5Kb)
Author
Butcher, Lee
Peres, Karine
Morris, Roger
Walter, Stefan
Dartigues, Jean-Francois
Rodriguez-Mañas, Leocadio
Feart, Catherine
Erusalimsky, Jorge
Date
2018-10-09
Acceptance date
2018-10-04
Type
Article
Publisher
Elsevier
Metadata
Show full item record
Abstract
The chemokine CCL11 has been implicated in age-related cognitive deterioration in mice, yet evidence on the relationship between CCL11 and cognitive function in humans is limited. This study explored associations between CCL11 and cognition in rural and urban community-dwelling older adults. Participants were 515 urban dwellers from the 3C-Bordeaux cohort and 318 rural dwellers from the AMI cohort. Plasma CCL11 was measured using an enzyme-linked immunoassay. Mini Mental State Examination (MMSE) test scores were used as the main measure of cognitive performance. Multivariate regression analysis was used to evaluate the cross-sectional association between CCL11 and cognitive performance. CCL11 was significantly higher in rural dwellers compared to city dwellers (median [IQR]: 145 [115–201] pg/mL vs. 103 [85–129] pg/mL; p < 0.001). After adjustment for confounders, CCL11 was found to be negatively associated with cognitive performance in rural dwellers but not in city dwellers. These results suggest that CCL11 may be an independent determinant of cognitive function in older rural dwellers and that the residential environment modifies this association.
Journal/conference proceeding
Experimental Gerontology;
Citation
Butcher, L., Peres, K., Morris, R., Walter, S., Dartigues, J-F., Rodriguez-Mañas, L., Feart, C. and Erusalimsky, J. (2018) 'Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers', Experimental Gerontology, Article in Press
URI
http://hdl.handle.net/10369/10134
DOI
https://doi.org/10.1016/j.exger.2018.10.004
Description
Article published as accepted manuscript in Experimental Gerontology on 09 October 2018 available at https://doi.org/10.1016/j.exger.2018.10.004
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
FRAILOMIC partnership
Collections
  • Health and Risk Management [392]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Cognitive processes and emotion cue processing in introvertive anhedonia 

    Skillicorn, Deiniol (University of WalesCardiff School of Health Sciences, 2010)
    Executive cognitive processes and emotion cue processing was explored in introvertive anhedonia, the O-LIFE’s negative schizotypal trait dimension, with the aim of identifying endophenotypes. The experimental work of the ...
  • Thumbnail

    Associations between schizotypal traits and antisocial behaviours in a sub-Saharan sample 

    Orjiakor, Charles; Watt, Andrew; Iorfa, Steven; Onu, Desmond; Okonkwo, Angela (Elsevier, 2019-10-21)
    Schizophrenic symptoms have often been associated with antisocial behaviours (ASBs). Most studies have focused on violence. The association between schizophrenia and violence is often confounded by socio demographic ...
  • Thumbnail

    Health related fitness and physical activity levels of urban and rural boys 

    Price, Carwyn (University of Wales Institute Cardiff, 2008)
    The study aimed to investigate the health related fitness level and physical activity behaviour of urban and rural Welsh schoolboys. The sample comprised of 31 urban and 21 rural boys, all aged 11-12 yrs. The health related ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator