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dc.contributor.authorButcher, Lee
dc.contributor.authorPeres, Karine
dc.contributor.authorMorris, Roger
dc.contributor.authorWalter, Stefan
dc.contributor.authorDartigues, Jean-Francois
dc.contributor.authorRodriguez-Mañas, Leocadio
dc.contributor.authorFeart, Catherine
dc.contributor.authorErusalimsky, Jorge
dc.date.accessioned2018-10-09T12:51:47Z
dc.date.available2018-10-09T12:51:47Z
dc.date.issued2018-10-09
dc.identifier.citationButcher, L., Peres, K., Morris, R., Walter, S., Dartigues, J-F., Rodriguez-Mañas, L., Feart, C. and Erusalimsky, J. (2018) 'Association between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellers', Experimental Gerontology, Article in Pressen_US
dc.identifier.urihttp://hdl.handle.net/10369/10134
dc.descriptionArticle published as accepted manuscript in Experimental Gerontology on 09 October 2018 available at https://doi.org/10.1016/j.exger.2018.10.004en_US
dc.description.abstractThe chemokine CCL11 has been implicated in age-related cognitive deterioration in mice, yet evidence on the relationship between CCL11 and cognitive function in humans is limited. This study explored associations between CCL11 and cognition in rural and urban community-dwelling older adults. Participants were 515 urban dwellers from the 3C-Bordeaux cohort and 318 rural dwellers from the AMI cohort. Plasma CCL11 was measured using an enzyme-linked immunoassay. Mini Mental State Examination (MMSE) test scores were used as the main measure of cognitive performance. Multivariate regression analysis was used to evaluate the cross-sectional association between CCL11 and cognitive performance. CCL11 was significantly higher in rural dwellers compared to city dwellers (median [IQR]: 145 [115–201] pg/mL vs. 103 [85–129] pg/mL; p < 0.001). After adjustment for confounders, CCL11 was found to be negatively associated with cognitive performance in rural dwellers but not in city dwellers. These results suggest that CCL11 may be an independent determinant of cognitive function in older rural dwellers and that the residential environment modifies this association.en_US
dc.description.sponsorshipFRAILOMIC partnershipen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesExperimental Gerontology;
dc.titleAssociation between plasma CCL11 (eotaxin-1) and cognitive status in older adults: Differences between rural and urban dwellersen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.exger.2018.10.004
dcterms.dateAccepted2018-10-04
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2018-10-09
rioxxterms.freetoread.startdate2019-10-09


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