• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition

Thumbnail
Author
Sprung, Victoria
Jones, Helen
Pugh, Christopher J. A.
Aziz, Nabil F.
Daousi, Christina
Kemp, Graham
Green, Daniel
Cable, Timothy
Cuthbertson, Daniel J.
Date
2014-01-31
Type
Article
Publisher
Portland Press
Metadata
Show full item record
Abstract
PCOS (polycystic ovary syndrome) is associated with IR (insulin resistance), increased visceral fat and NAFLD (non-alcoholic fatty liver disease) all of which may contribute to endothelial dysfunction, an early marker of CVD (cardiovascular disease) risk. Our objective was to examine the relationships between endothelial dysfunction in PCOS, the volume of AT (adipose tissue) compartments and the size of intracellular TAG (triacylglycerol) pools in liver and skeletal muscle. A total of 19 women with PCOS (means±S.D.; 26±6 years, 36±5 kg/m2) and 16 control women (31±8 years, 30±6 kg/m2) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT (subcutaneous AT) volume were determined by whole body MRI, and liver and skeletal muscle TAG by 1H-MRS (proton magnetic resonance spectroscopy). Cardiorespiratory fitness and HOMA-IR (homoeostasis model assessment of IR) were also determined. Differences between groups were analysed using independent Student's t tests and ANCOVA (analysis of co-variance). FMD was impaired in PCOS by 4.6% [95% CI (confidence interval), 3.0–7.7; P<0.001], and this difference decreased only slightly to 4.2% (95% CI, 2.4–6.1; P<0.001) when FMD was adjusted for individual differences in visceral and SAT and HOMA-IR. This magnitude of impairment was also similar in lean and obese PCOS women. The results suggest that endothelial dysfunction in PCOS is not explained by body fat distribution or volume. FMD might be a useful independent prognostic tool to assess CVD risk in this population.
Journal/conference proceeding
Clinical Science;
Citation
Sprung, V.S., Jones, H., Pugh, C.J., Aziz, N.F., Daousi, C., Kemp, G.J., Green, D.J., Cable, N.T. and Cuthbertson, D.J. (2014) 'Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition', Clinical Science, 126(1), pp.67-74
URI
http://hdl.handle.net/10369/10136
DOI
https://doi.org/10.1042/CS20130186
Description
Copy not available from this repository
Collections
  • Sport Research Groups [791]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes 

    Anderson, R.A.; Evans, Marc; Ellis, G.R.; Graham, J.; Morris, Keith; Jackson, S.K.; Lewis, M.J.; Rees, A.; Frenneaux, M.P. (Elsevier, 2001)
    Post-prandial lipaemia (PPL) is a factor in atherogenesis and results in reversible endothelial dysfunction in healthy individuals. Oxidative stress and triglyceride (TG)-rich lipoproteins have been implicated. Type 2 ...
  • Thumbnail

    SIRT6 protects human endothelial cells from DNA damage, telomere dysfunction, and senescence 

    Cardus, Anna; Uryga, Anna; Walters, Gareth; Erusalimsky, Jorge (Oxford University Press, 2013)
    AIMS: Although endothelial cell senescence is known to play an important role in the development of cardiovascular pathologies, mechanisms that attenuate this process have not been extensively investigated. The aim of this ...
  • Thumbnail

    The effect of alpha1-adrenergic blockade on post-exercise brachial artery flow-mediated dilatation at sea-level and high-altitude 

    Tymko, Michael; Tremblay, Joshua; Howe, Connor; Willie, Christopher; Stembridge, Mike; Green, Daniel; Hoiland, Ryan; Subedi, Prajan; Anholm, James; Ainslie, Philip (Wiley, 2016-11-07)
    We examined the hypotheses that 1) at rest, endothelial function would be impaired at high- altitude compared to sea-level, 2) endothelial function would be reduced to a greater extent at sea-level compared to high-altitude ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator