Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition
Pugh, Christopher J. A.
Aziz, Nabil F.
Cuthbertson, Daniel J.
MetadataDangos cofnod eitem llawn
PCOS (polycystic ovary syndrome) is associated with IR (insulin resistance), increased visceral fat and NAFLD (non-alcoholic fatty liver disease) all of which may contribute to endothelial dysfunction, an early marker of CVD (cardiovascular disease) risk. Our objective was to examine the relationships between endothelial dysfunction in PCOS, the volume of AT (adipose tissue) compartments and the size of intracellular TAG (triacylglycerol) pools in liver and skeletal muscle. A total of 19 women with PCOS (means±S.D.; 26±6 years, 36±5 kg/m2) and 16 control women (31±8 years, 30±6 kg/m2) were recruited. Endothelial function was assessed in the brachial artery using FMD (flow-mediated dilation). VAT (visceral AT) and abdominal SAT (subcutaneous AT) volume were determined by whole body MRI, and liver and skeletal muscle TAG by 1H-MRS (proton magnetic resonance spectroscopy). Cardiorespiratory fitness and HOMA-IR (homoeostasis model assessment of IR) were also determined. Differences between groups were analysed using independent Student's t tests and ANCOVA (analysis of co-variance). FMD was impaired in PCOS by 4.6% [95% CI (confidence interval), 3.0–7.7; P<0.001], and this difference decreased only slightly to 4.2% (95% CI, 2.4–6.1; P<0.001) when FMD was adjusted for individual differences in visceral and SAT and HOMA-IR. This magnitude of impairment was also similar in lean and obese PCOS women. The results suggest that endothelial dysfunction in PCOS is not explained by body fat distribution or volume. FMD might be a useful independent prognostic tool to assess CVD risk in this population.
Sprung, V.S., Jones, H., Pugh, C.J., Aziz, N.F., Daousi, C., Kemp, G.J., Green, D.J., Cable, N.T. and Cuthbertson, D.J. (2014) 'Endothelial dysfunction in hyperandrogenic polycystic ovary syndrome is not explained by either obesity or ectopic fat deposition', Clinical Science, 126(1), pp.67-74
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1042/CS20130186
Copy not available from this repository
- Sport Research Groups 
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
The relationships between post-prandial lipaemia, endothelial function and oxidative stress in healthy individuals and patients with type 2 diabetes Anderson, R.A.; Evans, Marc; Ellis, G.R.; Graham, J.; Morris, Keith; Jackson, S.K.; Lewis, M.J.; Rees, A.; Frenneaux, M.P. (Elsevier, 2001)Post-prandial lipaemia (PPL) is a factor in atherogenesis and results in reversible endothelial dysfunction in healthy individuals. Oxidative stress and triglyceride (TG)-rich lipoproteins have been implicated. Type 2 ...
Cardus, Anna; Uryga, Anna; Walters, Gareth; Erusalimsky, Jorge (Oxford University Press, 2013)AIMS: Although endothelial cell senescence is known to play an important role in the development of cardiovascular pathologies, mechanisms that attenuate this process have not been extensively investigated. The aim of this ...
Fibroblast growth factor-2, but not vascular endothelial growth factor, upregulates telomerase activity in human endothelial cells Kurz, D.J.; Hong, Y.; Trivier, E.; Huang, H.L.; Decary, S.; Zang, G.H.; Lüscher, T.F.; Erusalimsky, Jorge (Lippincott Williams & Wilkins, 2003)Objective— Telomerase plays a major role in the control of replicative capacity, a critical property for successful angiogenesis and maintenance of endothelial integrity. In this study, we examined the relationship between ...