• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome

Thumbnail
View/open
Publisher PDF (476.6Kb)
Author
Silva, Lindsay D.
Wilczynska, Maria
Lewis, Keir
Lawrence, Matthew
Hawkins, Karl
Williams, Rhodri
Stanford, Sophia
Davidson, Simon
Morris, Keith
Evans, Adrian
Date
2016-03
Acceptance date
2016-02-11
Type
Article
Publisher
Elsevier
Metadata
Show full item record
Abstract
Abnormal clot microstructure plays a pivotal role in the pathophysiology of thromboembolic diseases. Assessing the viscoelastic properties of clot microstructure using novel parameters, Time to Gel Point (TGP), Fractal Dimension (df) and clot elasticity (G׳GP) could explain the increased cardiovascular and thromboembolic events in patients with Obstructive Sleep Apnoea Hypopnea Syndrome (OSAHS). We wanted to compare TGP, df, and G׳GP and their diurnal variation in OSAHS and symptomatic comparators. thirty six patients attending a sleep disturbed breathing clinic with symptoms of OSAHS were recruited. TGP, df and G׳GP were measured alongside standard coagulation screening, thrombin generation assays, and platelet aggregometry at 16:00 h and immediately after an in-patient sleep study at 07:30 h. OSAHS group had significantly lower afternoon df than comparators (1.705±0.033 vs. 1.731±0.031, p<0.05). df showed diurnal variation and only in the OSAHS group, being significantly lower in the afternoon than morning (p<0.05). Diurnal changes in df correlated with 4% DR, even after controlling for BMI (r=0.37, p=0.02). The lower df in the afternoon in OSAHS suggests a partial compensatory change that may make up for other pro-clotting abnormalities/hypertension during the night. The change to the thrombotic tendency in the afternoon is biggest in severe OSAHS. df Shows promise as a new microstructural indicator for abnormal haemostasis in OSAHS.
Journal/conference proceeding
Sleep Science;
Citation
Wilczynska, M., Lewis, K., Lawrence, M., Hawkins, K., Williams, R., Stanford, S., Davidson, S., Morris, K. and Evans, A. (2016) 'Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome', Sleep Science, 9(1), pp.14-19
URI
http://hdl.handle.net/10369/10146
DOI
https://doi.org/10.1016/j.slsci.2016.02.175
Description
Article published open access in Sleep Science in March 2016 available open access at https://doi.org/10.1016/j.slsci.2016.02.175
Rights
https://creativecommons.org/licenses/by-nc-nd/4.0/
Collections
  • Health and Risk Management [391]

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator