Show simple item record

dc.contributor.authorSilva, Lindsay D.
dc.contributor.authorWilczynska, Maria
dc.contributor.authorLewis, Keir
dc.contributor.authorLawrence, Matthew
dc.contributor.authorHawkins, Karl
dc.contributor.authorWilliams, Rhodri
dc.contributor.authorStanford, Sophia
dc.contributor.authorDavidson, Simon
dc.contributor.authorMorris, Keith
dc.contributor.authorEvans, Adrian
dc.date.accessioned2018-10-24T18:48:35Z
dc.date.available2018-10-24T18:48:35Z
dc.date.issued2016-03
dc.identifier.citationWilczynska, M., Lewis, K., Lawrence, M., Hawkins, K., Williams, R., Stanford, S., Davidson, S., Morris, K. and Evans, A. (2016) 'Altered clot microstructure detected in obstructive sleep apnoea hypopnoea syndrome', Sleep Science, 9(1), pp.14-19en_US
dc.identifier.urihttp://hdl.handle.net/10369/10146
dc.descriptionArticle published open access in Sleep Science in March 2016 available open access at https://doi.org/10.1016/j.slsci.2016.02.175en_US
dc.description.abstractAbnormal clot microstructure plays a pivotal role in the pathophysiology of thromboembolic diseases. Assessing the viscoelastic properties of clot microstructure using novel parameters, Time to Gel Point (TGP), Fractal Dimension (df) and clot elasticity (G׳GP) could explain the increased cardiovascular and thromboembolic events in patients with Obstructive Sleep Apnoea Hypopnea Syndrome (OSAHS). We wanted to compare TGP, df, and G׳GP and their diurnal variation in OSAHS and symptomatic comparators. thirty six patients attending a sleep disturbed breathing clinic with symptoms of OSAHS were recruited. TGP, df and G׳GP were measured alongside standard coagulation screening, thrombin generation assays, and platelet aggregometry at 16:00 h and immediately after an in-patient sleep study at 07:30 h. OSAHS group had significantly lower afternoon df than comparators (1.705±0.033 vs. 1.731±0.031, p<0.05). df showed diurnal variation and only in the OSAHS group, being significantly lower in the afternoon than morning (p<0.05). Diurnal changes in df correlated with 4% DR, even after controlling for BMI (r=0.37, p=0.02). The lower df in the afternoon in OSAHS suggests a partial compensatory change that may make up for other pro-clotting abnormalities/hypertension during the night. The change to the thrombotic tendency in the afternoon is biggest in severe OSAHS. df Shows promise as a new microstructural indicator for abnormal haemostasis in OSAHS.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesSleep Science;
dc.titleAltered clot microstructure detected in obstructive sleep apnoea hypopnoea syndromeen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.slsci.2016.02.175
dcterms.dateAccepted2016-02-11
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2018-10-24


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record