Rebuttal (in Journal of Physiology)
Stöhr, Eric J.
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Cornwell et al.(2018) provide irrefutable arguments that the human circulation is able to survive44onlower arterial oscillations than the normal arterial pulsatility. Thus, we agree that a key aim for future research will be to determine the optimal amount of pulsatility for each individual CF-46LVAD patient. To ultimately achieve a personalized therapeutic target, the optimal balance 47between LVAD device settings (including its effects on native heart function) and the patient’s 48pre-existing peripheral arterial health will need to be considered. At present, the consistentlylow49pulsatility in CF-LVAD patients is, in our opinion, still of concern.