• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Import
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Import
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Cardiac Performance with Chronic Hypoxia: Mechanisms regulating stroke volume

Thumbnail
View/open
Author's post-print (1023.Kb)
Author
Stembridge, Mike
Levine, Benjamin
Date
2018-12-28
Acceptance date
2018-12-21
Type
Article
Publisher
Elsevier
ISSN
2468-8673
Metadata
Show full item record
Abstract
When humans are exposed to high altitude hypoxia for a sustained period, the cardiac stroke volume is reduced. The changes in cardiac performance seen at high altitude are a result of complex and concomitant changes in preload, afterload and contractility, although the precise mechanisms underpinning the decrease in stroke volume are not known despite being of scientific interest for over fifty years. In this review, we briefly revisit the seminal work performed in the area before focusing on recent developments that have applied mechanistic experimental models and novel imaging technologies to further understand why stroke volume is decreased in chronic hypoxia. First, the review focuses on systolic contractile function before considering the role of diastolic function and ventricular filling.
Journal/conference proceeding
Current Opinion in Physiology;
Citation
Stembridge, M. and Levine, B. (2018) 'Cardiac Performance with Chronic Hypoxia: Mechanisms regulating stroke volume', Current Opinion in Physiology. https://doi.org/10.1016/j.cophys.2018.12.007
URI
http://hdl.handle.net/10369/10203
DOI
https://doi.org/10.1016/j.cophys.2018.12.007
Description
Article published ahead of print in Current Opinion in Physiology available at https://doi.org/10.1016/j.cophys.2018.12.007
Rights
http://www.rioxx.net/licenses/under-embargo-all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
  • Import [797]

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator