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dc.contributor.authorStembridge, Mike
dc.contributor.authorLevine, Benjamin
dc.date.accessioned2019-01-08T11:31:41Z
dc.date.available2019-01-08T11:31:41Z
dc.date.issued2018-12-28
dc.identifier.citationStembridge, M. and Levine, B. (2018) 'Cardiac Performance with Chronic Hypoxia: Mechanisms regulating stroke volume', Current Opinion in Physiology. https://doi.org/10.1016/j.cophys.2018.12.007en_US
dc.identifier.issn2468-8673
dc.identifier.urihttp://hdl.handle.net/10369/10203
dc.descriptionArticle published ahead of print in Current Opinion in Physiology available at https://doi.org/10.1016/j.cophys.2018.12.007en_US
dc.description.abstractWhen humans are exposed to high altitude hypoxia for a sustained period, the cardiac stroke volume is reduced. The changes in cardiac performance seen at high altitude are a result of complex and concomitant changes in preload, afterload and contractility, although the precise mechanisms underpinning the decrease in stroke volume are not known despite being of scientific interest for over fifty years. In this review, we briefly revisit the seminal work performed in the area before focusing on recent developments that have applied mechanistic experimental models and novel imaging technologies to further understand why stroke volume is decreased in chronic hypoxia. First, the review focuses on systolic contractile function before considering the role of diastolic function and ventricular filling.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesCurrent Opinion in Physiology;
dc.titleCardiac Performance with Chronic Hypoxia: Mechanisms regulating stroke volumeen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.cophys.2018.12.007
dcterms.dateAccepted2018-12-21
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-12-28
rioxxterms.freetoread.startdate2019-12-28
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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