Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients
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Aim Obtain initial estimates of the change in brachial artery endothelial function and maximal oxygen uptake (VO2peak) with 8 weeks of low‐frequency electrical muscle stimulation (LF‐EMS) or sham in patients with advanced chronic heart failure. Methods and results Using a double blind, randomized design, 35 patients with chronic heart failure (New York Heart Association class III–IV) were assigned to 8 weeks (5 × 60 min per week) of either LF‐EMS (4 Hz, continuous) or sham (skin level stimulation only) of the quadriceps and hamstrings muscles. Four of the five sessions were at home and one under supervision. Ultrasound images of resting brachial artery diameter and post 5 min occlusion to determine flow‐mediated dilation (FMD), a marker of vascular function and peak oxygen uptake (VO2peak) during cardiopulmonary exercise test, were measured before and after LF‐EMS (n = 20) and sham (n = 15) interventions. FMD improved by 2.56% (95% confidence interval: 0.69 to 3.80) with LF‐EMS compared with sham (P = 0.07). There were no notable changes in VO2peak. Conclusions Improvements in FMD with LF‐EMS may have a clinically meaningful effect as higher FMD is associated with better prognosis. This is a preliminary finding, and a larger trial is warranted.
ESC Heart Failure;
Ennis, S., McGregor, G., Shave, R., McDonnell, B., Thompson, A., Banerjee, P. and Jones, H. (2018) 'Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients', ESC Heart Failure, 5(4), pp.727-731.
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1002/ehf2.12293
Article published in ESC Heart Failure available open access at https://doi.org/10.1002/ehf2.12293
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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Randomised feasibility trial into the effects of low-frequency electrical muscle stimulation in advanced heart failure patients Ennis, Stuart; McGregor, Gordon; Hamborg, Thomas; Jones, Helen; Shave, Rob; Singh, Sally; Banerjee, Prithwish (BMJ Open, 2017-08-11)Objectives Low-frequency electrical muscle stimulation (LF-EMS) may have the potential to reduce breathlessness and increase exercise capacity in the chronic heart failure population who struggle to adhere to conventional ...
Ventricular structure, function and mechanics at high altitude: chronic remodelling in Sherpa verses short-term lowlander adaptation. Awdur anhysbys (American Physiological Society, 2014-08-01)Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged ...
Ventricular structure, function, and mechanics at high altitude: chronic remodeling in Sherpa vs. short-term lowlander adaptation. Awdur anhysbys (American Physiological Society, 2014-08-01)Short-term, high-altitude (HA) exposure raises pulmonary artery systolic pressure (PASP) and decreases left-ventricular (LV) volumes. However, relatively little is known of the long-term cardiac consequences of prolonged ...