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dc.contributor.authorEnnis, Stuart
dc.contributor.authorMcGregor, Gordon
dc.contributor.authorShave, Rob
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorThompson, Andrew
dc.contributor.authorBanerjee, Prithwish
dc.contributor.authorJones, Helen
dc.date.accessioned2019-01-10T11:55:31Z
dc.date.available2019-01-10T11:55:31Z
dc.date.issued2018-07-03
dc.identifier.citationEnnis, S., McGregor, G., Shave, R., McDonnell, B., Thompson, A., Banerjee, P. and Jones, H. (2018) 'Low frequency electrical muscle stimulation and endothelial function in advanced heart failure patients', ESC Heart Failure, 5(4), pp.727-731.en_US
dc.identifier.issn2055-5822
dc.identifier.urihttp://hdl.handle.net/10369/10207
dc.descriptionArticle published in ESC Heart Failure available open access at https://doi.org/10.1002/ehf2.12293en_US
dc.description.abstractAim Obtain initial estimates of the change in brachial artery endothelial function and maximal oxygen uptake (VO2peak) with 8 weeks of low‐frequency electrical muscle stimulation (LF‐EMS) or sham in patients with advanced chronic heart failure. Methods and results Using a double blind, randomized design, 35 patients with chronic heart failure (New York Heart Association class III–IV) were assigned to 8 weeks (5 × 60 min per week) of either LF‐EMS (4 Hz, continuous) or sham (skin level stimulation only) of the quadriceps and hamstrings muscles. Four of the five sessions were at home and one under supervision. Ultrasound images of resting brachial artery diameter and post 5 min occlusion to determine flow‐mediated dilation (FMD), a marker of vascular function and peak oxygen uptake (VO2peak) during cardiopulmonary exercise test, were measured before and after LF‐EMS (n = 20) and sham (n = 15) interventions. FMD improved by 2.56% (95% confidence interval: 0.69 to 3.80) with LF‐EMS compared with sham (P = 0.07). There were no notable changes in VO2peak. Conclusions Improvements in FMD with LF‐EMS may have a clinically meaningful effect as higher FMD is associated with better prognosis. This is a preliminary finding, and a larger trial is warranted.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesESC Heart Failure;
dc.subjectadvanced heart failureen_US
dc.subjectcardiac rehabilitationen_US
dc.subjectendothelial function electrical muscle stimulationen_US
dc.subjectneuromuscular electrical stimulationen_US
dc.subjectflow-mediated dilationen_US
dc.titleLow frequency electrical muscle stimulation and endothelial function in advanced heart failure patientsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1002/ehf2.12293
dcterms.dateAccepted2018-03-29
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2019-01-10
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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