Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females
Enigma Study Investigators
American Heart Association
MetadataDangos cofnod eitem llawn
Blood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. All individuals undertook a lifestyle and medical history questionnaire and detailed metabolic, hemodynamic, and autonomic assessments. Stage 1 hypertension and normal BP were the most common BP phenotypes in males (29%) and females (68%), respectively. In both sexes, cardiac output was positively associated with increasing BP category (P<0.001 for both). Similar positive trends were observed for heart rate and stroke volume in males (P<0.001 for both) and heart rate in females (P<0.001). Unlike in males, peripheral vascular resistance, aortic pulse wave velocity, and augmentation index were significantly increased in hypertensive females (P<0.001 for all) compared with the other BP categories. Most heart rate variability indices decreased across the BP categories, particularly in males. In young adults, metabolic and hemodynamic abnormalities associated with hypertension are already present at the elevated BP stage and the overall phenotype differed markedly between sexes. Whereas a cardiac phenotype was associated with elevated BP and hypertension in males, a vascular phenotype, characterized by elevated peripheral vascular resistance, aortic pulse wave velocity, and augmentation index, was dominant in females.
Nardin, C., Maki-Petaja, K.M., Miles, K.L., Yasmin, McDonnell, B.J., Cockcroft, J.R., Wilkinson, I.B., McEniery, C.M. and Enigma Study Investigators (2018) 'Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females: The Enigma Study', Hypertension, 72(6), pp.1277-1284.
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1161/HYPERTENSIONAHA.118.11975
Article published in Hypertension, available open access at https://www.ahajournals.org/doi/suppl/10.1161/HYPERTENSIONAHA.118.11975
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.
Mechanisms underlying elevated systolic blood pressure differ with adiposity in young adults: The Enigma Study Hickson, Stacey S.; Nichols, Wilmer W.; Yasmin; McDonnell, Barry; Cockcroft, John R.; Wilkinson, Ian B.; McEniery, Carmel M. (Lippincot, Williams & Wilkins, 2016)Objectives: The positive association between adiposity and hypertension is well recognized. However, not all overweight individuals have elevated blood pressure (BP). Moreover, different factors may be associated with high ...
An investigation into the role of PPARγ and IL-6 in exercise-induced alterations in monocyte gene expression Ruffino, José (Cardiff Metropolitan University, 2015)The pro-inflammatory M1 macrophage phenotype is linked to insulin resistance, T2D and associated cardiovascular co-morbidities, whereas M2 macrophages regulate the M1 inflammatory response and are, thus, believed to be ...
Prevalence of metabolic risk factors and associated 10‐year prediction of cardiovascular disease and diabetes in female employees Gray, B.; Bracken, R.; Turner, D.; Morgan, K.; Mellalieu, Stephen D.; Thomas, M.; Williams, Sally P.; Williams, M.; Rice, S.; Stephens, J.W. (Wiley, 2014-09-08)Cardiovascular disease (CVD) and type 2 diabetes (T2DM) remain two of the greatest health challenges in the United Kingdom. Guidelines currently advocate screening individuals to identify those at ‘high risk’ (10‐year risk ...