Show simple item record

dc.contributor.authorNardin, C.
dc.contributor.authorMaki-Petaja, K.M.
dc.contributor.authorMiles, K.L.
dc.contributor.authorYasmin
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorCockcroft, J.R.
dc.contributor.authorWilkinson, I.B.
dc.contributor.authorMcEniery, C.M.
dc.contributor.authorEnigma Study Investigators
dc.date.accessioned2019-01-11T11:06:37Z
dc.date.available2019-01-11T11:06:37Z
dc.date.issued2018-10-15
dc.identifier.citationNardin, C., Maki-Petaja, K.M., Miles, K.L., Yasmin, McDonnell, B.J., Cockcroft, J.R., Wilkinson, I.B., McEniery, C.M. and Enigma Study Investigators (2018) 'Cardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Females: The Enigma Study', Hypertension, 72(6), pp.1277-1284.en_US
dc.identifier.issn0194-911X
dc.identifier.issn1524-4563 (online)
dc.identifier.urihttp://hdl.handle.net/10369/10210
dc.descriptionArticle published in Hypertension, available open access at https://www.ahajournals.org/doi/suppl/10.1161/HYPERTENSIONAHA.118.11975en_US
dc.description.abstractBlood pressure (BP) in young adults predicts BP in later life. We aimed to identify metabolic, hemodynamic, and autonomic characteristics associated with raised BP in young adults and whether these differ between males and females. Three thousand one hundred forty-five healthy subjects, aged 18 to 40 years, were grouped according to sex and BP category following the recent reclassification of BP as part of American Heart Association/American College of Cardiology 2017 guidelines. All individuals undertook a lifestyle and medical history questionnaire and detailed metabolic, hemodynamic, and autonomic assessments. Stage 1 hypertension and normal BP were the most common BP phenotypes in males (29%) and females (68%), respectively. In both sexes, cardiac output was positively associated with increasing BP category (P<0.001 for both). Similar positive trends were observed for heart rate and stroke volume in males (P<0.001 for both) and heart rate in females (P<0.001). Unlike in males, peripheral vascular resistance, aortic pulse wave velocity, and augmentation index were significantly increased in hypertensive females (P<0.001 for all) compared with the other BP categories. Most heart rate variability indices decreased across the BP categories, particularly in males. In young adults, metabolic and hemodynamic abnormalities associated with hypertension are already present at the elevated BP stage and the overall phenotype differed markedly between sexes. Whereas a cardiac phenotype was associated with elevated BP and hypertension in males, a vascular phenotype, characterized by elevated peripheral vascular resistance, aortic pulse wave velocity, and augmentation index, was dominant in females.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofseriesHypertension;
dc.subjecthypertensionen_US
dc.subjectvascular stiffnessen_US
dc.subjectcardiac outputen_US
dc.subjectvascular resistanceen_US
dc.titleCardiovascular Phenotype of Elevated Blood Pressure Differs Markedly Between Young Males and Femalesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1161/HYPERTENSIONAHA.118.11975
dcterms.dateAccepted2018-09-19
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-01-11
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


Files in this item

Thumbnail

This item appears in the following collection(s)

Show simple item record