Prolonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in rats
MetadataShow full item record
BACKGROUND: Exposure to air pollution is associated with cardiovascular disease, including increased morbidity and mortality rates. OBJECTIVE: The aim of this investigation was to assess the effect, in rats, of intratracheal instillation of particulate air pollution on biomarkers of leucocyte activation and vascular endothelial damage. METHODS: Air pollution particles (PM10) were instilled into rats, and blood samples were taken three days and six weeks post instillation. Plasma neutrophil elastase and VonWillebrand factor were measured by ELISA. RESULTS: Plasma neutrophil elastase increased from 175±44 ng/ml at baseline to 288±26 ng/ml 3 days post instillation (p=0.038). vWF increased from 0.160±0.015 IU/ml at baseline to 0.224±0.015 IU/ml at 3 days post and 0.208±0.01 IU/ml at 6 weeks post (p=0.006, ANOVA). sICAM-1 increased from 17.75±0.70 ng/ml at baseline to 19.03±0.33 ng/ml at 3 days post and 21.72±1.16 ng/ml at 6 weeks post (p=0.009, ANOVA). CONCLUSION: Instillation caused prolonged systemic inflammation, activation of blood leucocytes and damage to the vascular endothelium.
Clinical Hemorheology and Microcirculation;
Adams, R.A., Potter, S., Bérubé, K., Higgins, T.P., Jones, T., and Evans, S-A. (2018) 'Prolonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in rats', Clinical Hemorheology and Microcirculation. https://dx.doi.org/10.3233/CH-180377
Article published in Clinical Hemorheology and Microcirculation, available at https://dx.doi.org/10.3233/CH-180377
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Showing items related by title, author, subject and abstract.
Increased monocyte actin polymerization in rat blood after intratracheal instillation of air pollution particles Adams, Rachel; Al-Mosawi, Ameena; Bérubé, Kelly; Jones, Tim; Higgins, Timothy; Evans, Shelley-Ann (IOS Press Content Library, 2014)BACKGROUND: Exposure to particulate air pollution is associated with an increased risk of cardiovascular disease. The mechanism by which exposure increases risk is poorly understood but could involve changes in the flow ...
Al Bulushi, Halima (Cardiff Metropolitan University, 2010)In epidemiological studies in humans, increased exposure to airborne particulate matter is associated with increases in cardiovascular malfunction, hospital admissions and morbidity and mortality rates. Although different ...
Al-Mosawi, Ameena (Cardiff Metropolitan University, 2003)Leukocytes become activated in response to hazards such as bacteria, viruses and particulates, and this activation results in reduced blood flow in disease states. This activation is associated with assembly of the ...