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dc.contributor.authorAdams, Rachel
dc.contributor.authorPotter, Stephen
dc.contributor.authorBerube, Kelly
dc.contributor.authorJones, Tim
dc.contributor.authorEvans, Shelley-Ann
dc.date.accessioned2019-01-17T09:07:12Z
dc.date.available2019-01-17T09:07:12Z
dc.date.issued2018-12-21
dc.identifier.citationAdams, R.A., Potter, S., Bérubé, K., Higgins, T.P., Jones, T., and Evans, S-A. (2018) 'Prolonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in rats', Clinical Hemorheology and Microcirculation. https://dx.doi.org/10.3233/CH-180377en_US
dc.identifier.issn1386-0291
dc.identifier.issn1875-8622 (online)
dc.identifier.urihttp://hdl.handle.net/10369/10215
dc.descriptionArticle published in Clinical Hemorheology and Microcirculation, available at https://dx.doi.org/10.3233/CH-180377en_US
dc.description.abstractBACKGROUND: Exposure to air pollution is associated with cardiovascular disease, including increased morbidity and mortality rates. OBJECTIVE: The aim of this investigation was to assess the effect, in rats, of intratracheal instillation of particulate air pollution on biomarkers of leucocyte activation and vascular endothelial damage. METHODS: Air pollution particles (PM10) were instilled into rats, and blood samples were taken three days and six weeks post instillation. Plasma neutrophil elastase and VonWillebrand factor were measured by ELISA. RESULTS: Plasma neutrophil elastase increased from 175±44 ng/ml at baseline to 288±26 ng/ml 3 days post instillation (p=0.038). vWF increased from 0.160±0.015 IU/ml at baseline to 0.224±0.015 IU/ml at 3 days post and 0.208±0.01 IU/ml at 6 weeks post (p=0.006, ANOVA). sICAM-1 increased from 17.75±0.70 ng/ml at baseline to 19.03±0.33 ng/ml at 3 days post and 21.72±1.16 ng/ml at 6 weeks post (p=0.009, ANOVA). CONCLUSION: Instillation caused prolonged systemic inflammation, activation of blood leucocytes and damage to the vascular endothelium.en_US
dc.language.isoenen_US
dc.publisherIOS pressen_US
dc.relation.ispartofseriesClinical Hemorheology and Microcirculation;
dc.subjectParticlesen_US
dc.subjectcardiovascular diseaseen_US
dc.subjectinflammationen_US
dc.subjectendothelial damageen_US
dc.subjectleucocyteen_US
dc.titleProlonged systemic inflammation and damage to the vascular endothelium following intratracheal instillation of air pollution nanoparticles in ratsen_US
dc.typeArticleen_US
dc.identifier.doihttps://dx.doi.org/10.3233/CH-180377
dcterms.dateAccepted2018-11-30
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-01-17
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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