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dc.contributor.authorNamasivayam, M.
dc.contributor.authorMcEniery, C.M.
dc.contributor.authorWilkinson, Ian B.
dc.contributor.authorYasmin
dc.contributor.authorCockroft, John
dc.contributor.authorMcDonnell, Barry
dc.contributor.authorAdji, Audrey
dc.contributor.authorO’Rourke, M.F.
dc.contributor.authorAnglo-Cardiff Collaborative Trial Investigators
dc.date.accessioned2019-01-18T10:15:01Z
dc.date.available2019-01-18T10:15:01Z
dc.date.issued2018-10-22
dc.identifier.citationNamasivayam, M., McEniery, C.M., Wilkinson, I.B., Yasmin, Cockroft, J.R., McDonnell, B.J., Adji, A., O’Rourke, M.F. and Anglo-Cardiff Collaborative Trial Investigators (2018) 'Different Effects of Vascular Aging on Ischemic Predisposition in Healthy Men and Women', Hypertension, 72(6), pp.1294-1300en_US
dc.identifier.issn0194-911X
dc.identifier.issn1524-4563 (online)
dc.identifier.urihttp://hdl.handle.net/10369/10222
dc.descriptionArticle published in Hypertension, available at https://doi.org/10.1161/HYPERTENSIONAHA.118.11642en_US
dc.description.abstractInvasive studies of the twentieth century showed the value of aortic pressure-time integrals as markers of myocardial oxygen demand and supply. More recent studies have used these concepts to evaluate the mechanisms of ischemic predisposition using noninvasive arterial tonometry in cardiology outpatients. We sought to evaluate the spectrum of myocardial oxygen demand and supply in a large cross-sectional community sample of healthy volunteers and identify the roles of age, sex, and wave reflection. Arterial tonometry was performed in 3682 healthy volunteers. Measures of systolic and diastolic pressure-time integrals and their ratio in addition to cardiac ejection duration were determined and analyzed by age and sex. Multiple regression analyses were performed to identify the mechanisms underlying observations, while controlling for confounders (heart rate, height, weight, and mean pressure). In a healthy cohort, older women more than men (P<0.001) had unfavorable myocardial oxygen supply:demand ratios because of differing effects of vascular aging.en_US
dc.language.isoenen_US
dc.publisherAmerican Heart Associationen_US
dc.relation.ispartofseriesHypertension;
dc.subjectwomenen_US
dc.subjecthemodynamicsen_US
dc.subjectischemiaen_US
dc.subjectagingen_US
dc.subjectvascular stiffnessen_US
dc.titleDifferent Effects of Vascular Aging on Ischemic Predisposition in Healthy Men and Womenen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1161/HYPERTENSIONAHA.118.11642
dcterms.dateAccepted2018-09-24
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-04-22
rioxxterms.freetoread.startdate2019-04-22
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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