Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries

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Author
Drane, Aimee L.
Atencia, Rebeca
Cooper, Stephen-Mark
Rodriguez, Pablo
Sanchez, Carlos
Simcox, Sarah
Feltrer, Yedra
Peck, Bruce
Eng, Jaclyn
Moittie, Sophie
Unwin, Steve
Howatson, Glyn
Oxborough, David
Stembridge, Mike
Shave, Rob
Date
2019-06Acceptance date
2018-11-23
Type
Article
Publisher
American Veterinary Medical Association
ISSN
1943-5681
Embargoed until
2100-01-01
Metadata
Show full item recordAbstract
Objective: To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries. Animals: 290 wild-born captive chimpanzees. Procedures: Physical and echocardiographic examinations were performed on anesthetized chimpanzees in 3 sanctuaries in Africa between October 2013 and May 2017. Results were evaluated across age groups and between sexes, and potential differences were assessed with multiple 1-way independent Kruskal-Wallis tests. Results: Results indicated that left ventricular diastolic and systolic function declined at a younger age in males than in females. Although differences in right ventricular diastolic function were not identified among age groups, right ventricular systolic function was lower in adult chimpanzees (> 12 years old), compared with subadult (8 to 12 years old) and juvenile (5 to 7 years old) chimpanzees. In addition, male subadult and adult chimpanzees had larger cardiac wall dimensions and chamber volumes than did their female counterparts. Conclusions and Clinical Relevance: Results of the present study provided useful reference intervals for cardiac structure and function in captive chimpanzees categorized on the basis of age and sex; however, further research is warranted to examine isolated and combined impacts of blood pressure, age, body weight, and anaesthetic agents on cardiac structure and function in chimpanzees.
Journal/conference proceeding
American Journal of Veterinary Research;
Citation
Drane, A.L., Atencia, R., Cooper, S-M., Rodriguez, P., Sanchez, C., Simcox, S., Feltrer, Y., Peck, B., Eng, J., Moittie, S., Unwin, S., Howatson, G., Oxborough, D., Stembridge, M.R. and Shave, R.E. (In Press) ‘Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries’, American Journal of Veterinary Research. 80, (6), pp. 547-557. https://doi.org/10.2460/ajvr.80.6.547
Description
Article published in American Journal of Veterinary Research available at https://doi.org/10.2460/ajvr.80.6.547
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Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
International Primate Heart Project
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- Sport Research Groups [1096]
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