Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries
Drane, Aimee L.
American Veterinary Medical Association
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Objective: To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries. Animals: 290 wild-born captive chimpanzees. Procedures: Physical and echocardiographic examinations were performed on anesthetized chimpanzees in 3 sanctuaries in Africa between October 2013 and May 2017. Results were evaluated across age groups and between sexes, and potential differences were assessed with multiple 1-way independent Kruskal-Wallis tests. Results: Results indicated that left ventricular diastolic and systolic function declined at a younger age in males than in females. Although differences in right ventricular diastolic function were not identified among age groups, right ventricular systolic function was lower in adult chimpanzees (> 12 years old), compared with subadult (8 to 12 years old) and juvenile (5 to 7 years old) chimpanzees. In addition, male subadult and adult chimpanzees had larger cardiac wall dimensions and chamber volumes than did their female counterparts. Conclusions and Clinical Relevance: Results of the present study provided useful reference intervals for cardiac structure and function in captive chimpanzees categorized on the basis of age and sex; however, further research is warranted to examine isolated and combined impacts of blood pressure, age, body weight, and anaesthetic agents on cardiac structure and function in chimpanzees.
American Journal of Veterinary Research;
Drane, A.L., Atencia, R., Cooper, S-M., Rodriguez, P., Sanchez, C., Simcox, S., Feltrer, Y., Peck, B., Eng, J., Moittie, S., Unwin, S., Howatson, G., Oxborough, D., Stembridge, M.R. and Shave, R.E. (In Press) ‘Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries’, American Journal of Veterinary Research. 80, (6), pp. 547-557. https://doi.org/10.2460/ajvr.80.6.547
Article published in American Journal of Veterinary Research available at https://doi.org/10.2460/ajvr.80.6.547
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
International Primate Heart Project
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