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dc.contributor.authorNoakes, Zoe
dc.contributor.authorKeefe, Francesca
dc.contributor.authorTamburini, Claudia
dc.contributor.authorKelly, Claire
dc.contributor.authorMaria, Cruz Santos
dc.contributor.authorDunnett, Stephen
dc.contributor.authorErrington, Adam
dc.contributor.authorMeng, Li
dc.date.accessioned2019-02-05T10:53:35Z
dc.date.available2019-02-05T10:53:35Z
dc.date.issued2019-01-17
dc.identifier.citationNoakes, Z., Keefe, F., Tamburini, C., Kelly, C.M., Santos, M.C., Dunnett, S.B., Errington, A.C. and Li, M. (2019) ‘Human pluripotent stem cell-derived striatal interneurons: differentiation and maturation in vitro and in the rat brain’, Stem Cell Reports. DOI: 10.1016/j.stemcr.2018.12.014.en_US
dc.identifier.issn2213-6711
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2213671118305332
dc.identifier.urihttp://hdl.handle.net/10369/10270
dc.descriptionArticle published in Stem Cell Reports on 17 January 2019 (online), available open access at: https://doi.org/10.1016/j.stemcr.2018.12.014.en_US
dc.description.abstractStriatal interneurons are born in the medial and caudal ganglionic eminences (MGE and CGE) and play an important role in human striatal function and dysfunction in Huntington’s disease and dystonia. MGE/CGE-like neural progenitors have been generated from human pluripotent stem cells (hPSCs) for studying cortical interneuron development and cell therapy for epilepsy and other neurodevelopmental disorders. Here, we report the capacity of hPSC-derived MGE/CGE-like progenitors to differentiate into functional striatal interneurons. In vitro, these hPSC neuronal derivatives expressed cortical and striatal interneuron markers at the mRNA and protein level and displayed maturing electrophysiological properties. Following transplantation into neonatal rat striatum, progenitors differentiated into striatal interneuron subtypes and were consistently found in the nearby septum and hippocampus. These findings highlight the potential for hPSC-derived striatal interneurons as an invaluable tool in modeling striatal development and function in vitro or as a source of cells for regenerative medicine.en_US
dc.description.sponsorshipThis work was supported by the UK Medical Research Council.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofseriesStem Cell Reports;
dc.titleHuman Pluripotent Stem Cell-Derived Striatal Interneurons: Differentiation and Maturation In Vitro and in the Rat Brainen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1016/j.stemcr.2018.12.014
dcterms.dateAccepted2018-12-18
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-02-05


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