Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device
Stöhr, Eric J.
Cockcroft, John R.
Reshad Garan, A.
Topkara, Veli K.
Demmer, Ryan T.
Willey, Joshua Z.
Colombo, Paolo C.
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BACKGROUND Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients. METHODS We retrospectively studied 220 HMII patients. Serial outpatient BP measurements were averaged. Patients were categorized by: (1) mean arterial pressure (MAP), high (>90 mm Hg) vs intermediate (80 mm Hg ≤ MAP ≤ 90 mm Hg) vs low (<80 mm Hg); (2) systolic BP (SBP), high (≥101 mm Hg, median) vs low; and (3) pulse pressure (PP), high (≥22 mm Hg, median) vs low. To assess visit-to-visit BP variability, patients were divided in quartiles of standard deviation of MAP and SBP. The primary end-point was the composite of stroke or suspected pump thrombosis. RESULTS The risk for the primary end-point was increased in the high MAP group (adjusted hazard ratio [HR] 2.75, 95% confidence interval [CI] 1.49 to 5.05, vs intermediate MAP; and 6.73, 1.9 to 23.9, vs low MAP). MAP had higher predictive value for the primary end-point compared with SBP (p = 0.05). Patients with high SBP had a higher rate of stroke (HR 2.8, 95% CI 1.09 to 7.17, vs low SBP). The combination of high SBP and low PP was associated with the highest risk for stroke. The lowest quartile of visit-to-visit MAP variability was associated with the highest risk for the primary end-point. CONCLUSIONS Elevated outpatient BP is associated with increased risk for stroke or suspected pump thrombosis in HMII recipients. Reduced PP and low visit-to-visit BP variability may confer additional risk.
Journal of Heart and Lung Transplantation;
Pinsino, A., Castagna, F., Zuver, A.M., Royzman, E.A., Nasiri, M., Stöhr, E.J., Cagliostro, B., McDonnell, B., Cockcroft, J.R., Garan, A.R. and Topkara, V.K. (2018) 'Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device', Journal of Heart and Lung Transplantation, 38(4), p.396-405. DOI: 10.1016/j.healun.2018.11.003.
Article published in Journal of Heart and Lung Transplantation on 15 November 2018 (online), freely available at: https://doi.org/10.1016/j.healun.2018.11.003.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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