• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Sport Research Groups
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device

Thumbnail
Author
Pinsino, Alberto
Castagna, Francesco
Zuver, Amelia
Royzman, Eugene
Nasiri, Mojdeh
Stöhr, Eric J.
Cagliostro, Barbara
McDonnell, Barry
Cockcroft, John R.
Reshad Garan, A.
Topkara, Veli K.
Schulze, Christian
Takeda, Koji
Takayama, Hiroo
Naka, Yoshifumi
Demmer, Ryan T.
Willey, Joshua Z.
Yuzefpolskaya, Melana
Colombo, Paolo C.
Date
2018-11-15
Acceptance date
2018
Type
Article
Publisher
Elsevier
ISSN
1557-3117
Metadata
Show full item record
Abstract
BACKGROUND Elevated blood pressure (BP) has been linked to adverse events during left ventricular assist device support. In this study we investigated the association between outpatient BP and stroke or suspected pump thrombosis among HeartMate II (HMII) recipients. METHODS We retrospectively studied 220 HMII patients. Serial outpatient BP measurements were averaged. Patients were categorized by: (1) mean arterial pressure (MAP), high (>90 mm Hg) vs intermediate (80 mm Hg ≤ MAP ≤ 90 mm Hg) vs low (<80 mm Hg); (2) systolic BP (SBP), high (≥101 mm Hg, median) vs low; and (3) pulse pressure (PP), high (≥22 mm Hg, median) vs low. To assess visit-to-visit BP variability, patients were divided in quartiles of standard deviation of MAP and SBP. The primary end-point was the composite of stroke or suspected pump thrombosis. RESULTS The risk for the primary end-point was increased in the high MAP group (adjusted hazard ratio [HR] 2.75, 95% confidence interval [CI] 1.49 to 5.05, vs intermediate MAP; and 6.73, 1.9 to 23.9, vs low MAP). MAP had higher predictive value for the primary end-point compared with SBP (p = 0.05). Patients with high SBP had a higher rate of stroke (HR 2.8, 95% CI 1.09 to 7.17, vs low SBP). The combination of high SBP and low PP was associated with the highest risk for stroke. The lowest quartile of visit-to-visit MAP variability was associated with the highest risk for the primary end-point. CONCLUSIONS Elevated outpatient BP is associated with increased risk for stroke or suspected pump thrombosis in HMII recipients. Reduced PP and low visit-to-visit BP variability may confer additional risk.
Journal/conference proceeding
Journal of Heart and Lung Transplantation;
Citation
Pinsino, A., Castagna, F., Zuver, A.M., Royzman, E.A., Nasiri, M., Stöhr, E.J., Cagliostro, B., McDonnell, B., Cockcroft, J.R., Garan, A.R. and Topkara, V.K. (2018) 'Prognostic implications of serial outpatient blood pressure measurements in patients with an axial continuous-flow left ventricular assist device', Journal of Heart and Lung Transplantation, 38(4), p.396-405. DOI: 10.1016/j.healun.2018.11.003.
URI
http://hdl.handle.net/10369/10398
DOI
https://doi.org/10.1016/j.healun.2018.11.003
Description
Article published in Journal of Heart and Lung Transplantation on 15 November 2018 (online), freely available at: https://doi.org/10.1016/j.healun.2018.11.003.
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
  • Sport Research Groups [1088]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    The changes in clot microstructure in patients with ischaemic stroke and the effects of therapeutic intervention: a prospective observational study 

    Stanford, Sophia N.; Sabra, Ahmed; D'Silva, Lindsay; Lawrence, Matthew; Morris, Keith; Storton, Sharon; Brown, Martin R.; Evans, Vanessa; Hawkins, Karl; Williams, Phylip Rhodri; Davidson, Simon J.; Wani, Mushtaq; Potter, John F.; Evans, Phillip A. (BioMed Central, 2015-03-15)
    Background Stroke is the second largest cause of death worldwide. Hypercoagulability is a key feature in ischaemic stroke due to the development of an abnormally dense clot structure but techniques assessing the mechanics ...
  • Thumbnail

    Assessment of platelet function in patients with stroke using multiple electrode platelet aggregometry: a prospective observational study 

    Sabra, Ahmed; Stanford, Sophia N.; Lawrence, Matthew; D'Silva, Lindsay; Morris, Keith; Evans, Vanessa; Wani, Mushtaq; Potter, John F.; Evans, Phillip A. (BioMed Cental, 2016-12-09)
    Background There is a link between high on-treatment platelet reactivity (HPR) and adverse vascular events in stroke. This study aimed to compare multiple electrode platelet aggregometry (MEA), in healthy subjects and ...
  • Thumbnail

    A multicentre, observational evaluation of the product characteristics of two absorbent foam dressings 

    Seckam, Abdul (Mark Allen Healthcare, 2019-06-26)
    Wound healing is an intrinsic and dynamic process. Wound exudate is a normal feature of wound healing; however, when there is insufficient or excessive production, or the composition of the exudate is harmful, wound healing ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator