Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial
Taylor and Francis
MetadataShow full item record
Dietary nitrate may improve exercise tolerance in some healthy and clinical populations. Existing data regarding dietary nitrate in COPD is inconsistent. We conducted a 14d double-blind, randomised, placebo-controlled, crossover trial of daily nitrate-rich beetroot juice (BRJ; 12.9 mmol) versus nitrate-depleted BRJ (PL; 0.5 mmol). At baseline and after each condition, we assessed functional capacity (incremental shuttle walk test; ISWT), ambulatory blood pressure, pulmonary function, quality of life as well as exhaled nitric oxide (eNO), and plasma nitrate/nitrite (NOx). Eight subjects with COPD completed the trial. BRJ supplementation was associated with significantly increased NOx (p < .05) and a 14.6% increase in ISWT distance (+56 m, p = .00004) as well as a trend towards increased eNO compared to PL. There was no other differences. Dietary nitrate appears to have ergogenic effect in subjects with mild-moderate COPD. This effect does not appear to be related to altering blood pressure or pulmonary function.
International Journal of Food Sciences and Nutrition;
Kerley, C.P., James, P.E., McGowan, A., Faul, J. and Cormican, L. (2019) 'Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial', International Journal of Food Sciences and Nutrition, 70(2), pp.222-231. DOI: 10.1080/09637486.2018.1492521.
Article published in International Journal of Food Sciences and Nutrition on 06 September 2018 (online), available at: https://doi.org/10.1080/09637486.2018.1492521.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Showing items related by title, author, subject and abstract.
Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7d, double-blind, randomized, placebo-controlled, crossover trial Kerley, C.P.; Dolan, D.; James, Philip; Cormican, L. (Cambridge University Press, 2018-03-19)Dietary nitrate has been shown to increase nitrate/nitrite levels and decrease blood pressure (BP) in multiple populations. There are few reports among hypertensives and these reports have provided conflicting evidence. ...
Dietary nitrate supplementation reduces circulating platelet-derived extracellular vesicles in coronary artery disease patients on clopidogrel therapy Burnley-Hall, Nicholas; Abdul, Fairoz; Androshu, Vitaliy; Morris, Keith; Ossei-Gerning, Nicholas; Anderson, Richard; Rees, D. Aled; James, Philip (Schattauer, 2018-01-05)Summary Extracellular vesicles (EVs) are implicated in the pathogenesis of cardiovascular disease (CVD). Specifically, platelet-derived EVs are highly pro-coagulant, promoting thrombin generation and fibrin clot formation. ...
The effects of dietary nitrate supplementation on the adaptations to sprint interval training in previously untrained males Muggeridge, David; Sculthorpe, Nicholas; James, Philip; Easton, Chris (Elsevier, 2016-05-21)Objectives = Dietary nitrate can improve repeated high-intensity and supramaximal exercise performance, although the effect on adaptations to training has received limited attention. The purpose of this study was to ...