Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial
Taylor and Francis
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Dietary nitrate may improve exercise tolerance in some healthy and clinical populations. Existing data regarding dietary nitrate in COPD is inconsistent. We conducted a 14d double-blind, randomised, placebo-controlled, crossover trial of daily nitrate-rich beetroot juice (BRJ; 12.9 mmol) versus nitrate-depleted BRJ (PL; 0.5 mmol). At baseline and after each condition, we assessed functional capacity (incremental shuttle walk test; ISWT), ambulatory blood pressure, pulmonary function, quality of life as well as exhaled nitric oxide (eNO), and plasma nitrate/nitrite (NOx). Eight subjects with COPD completed the trial. BRJ supplementation was associated with significantly increased NOx (p < .05) and a 14.6% increase in ISWT distance (+56 m, p = .00004) as well as a trend towards increased eNO compared to PL. There was no other differences. Dietary nitrate appears to have ergogenic effect in subjects with mild-moderate COPD. This effect does not appear to be related to altering blood pressure or pulmonary function.
International Journal of Food Sciences and Nutrition;
Kerley, C.P., James, P.E., McGowan, A., Faul, J. and Cormican, L. (2019) 'Dietary nitrate improved exercise capacity in COPD but not blood pressure or pulmonary function: a 2 week, double-blind randomised, placebo-controlled crossover trial', International Journal of Food Sciences and Nutrition, 70(2), pp.222-231. DOI: 10.1080/09637486.2018.1492521.
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1080/09637486.2018.1492521
Article published in International Journal of Food Sciences and Nutrition on 06 September 2018 (online), available at: https://doi.org/10.1080/09637486.2018.1492521.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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Dietary nitrate lowers ambulatory blood pressure in treated, uncontrolled hypertension: a 7d, double-blind, randomized, placebo-controlled, crossover trial Kerley, C.P.; Dolan, D.; James, Philip; Cormican, L. (Cambridge University Press, 2018-03-19)Dietary nitrate has been shown to increase nitrate/nitrite levels and decrease blood pressure (BP) in multiple populations. There are few reports among hypertensives and these reports have provided conflicting evidence. ...
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