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dc.contributor.authorEissa, Ahmed
dc.contributor.authorBlaxland, James
dc.contributor.authorWilliams, Rhodri
dc.contributor.authorMetwally, Kamel
dc.contributor.authorEl-Adl, Sobhy
dc.contributor.authorLashine, El-Sayed
dc.contributor.authorBaillie, Leslie
dc.contributor.authorSimons, Claire
dc.date.accessioned2019-04-12T09:50:40Z
dc.date.available2019-04-12T09:50:40Z
dc.date.issued2016-02-22
dc.identifier.citationEissa, A.G., Blaxland, J.A., Williams, R.O., Metwally, K.A., El-Adl, S.M., Lashine, E.S.M., Baillie, L.W. and Simons, C. (2016) 'Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives. Journal of enzyme inhibition and medicinal chemistry', 31(6), pp.1694-1697. DOI: 10.3109/14756366.2016.1140754.en_US
dc.identifier.issn1475-6374
dc.identifier.urihttp://hdl.handle.net/10369/10418
dc.descriptionArticle published in Journal of Enzyme Inhibition and Medicinal Chemistry on 22 February 2016, available open access at: https://doi.org/10.3109/14756366.2016.1140754.en_US
dc.description.abstractThe synthesis of a series of benzimidazole-N-benzylpropan-1-amines and adenine-N-benzylpropan-1-amines is described. Subsequent evaluation against two strains of the anaerobic bacterium Clostridium difficile was performed with three amine derivatives displaying MIC values of 16 μg/mL. Molecular docking studies of the described amines determined that the amines interact within two active site pockets of C. difficile methionyl tRNA synthetase with methoxy substituents in the benzyl ring and an adenine biaryl moiety resulting in optimal binding interactions.en_US
dc.language.isoenen_US
dc.publisherTaylor and Francisen_US
dc.relation.ispartofseriesJournal of Enzyme Inhibition and Medicinal Chemistry;
dc.titleTargeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-Nbenzylpropan- 1-amine derivativesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3109/14756366.2016.1140754
dcterms.dateAccepted2016-01-05
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-04-12


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