Non-antibiotic antimicrobial interventions and antimicrobial stewardship in wound care
Mark Allen Healthcare
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Control of wound infection today relies largely on antibiotics, but the continual emergence of antibiotic-resistant microorganisms threatens a return to the pre-antibiotic era when physicians used antiseptics to prevent and manage infection. Some of those antiseptics are still used today, and others have become available. A diverse variety of non-antibiotic antimicrobial interventions are found on modern formularies. Unlike the mode of action of antibiotics, which affect specific cellular target sites of pathogens, many non-antibiotic antimicrobials affect multiple cellular target sites in a non-specific way. Although this reduces the likelihood of selecting for resistant strains of microorganisms, some have emerged and cross-resistance between antibiotics and antiseptics has been detected. With the prospect of a post-antibiotic era looming, ways to maintain and extend our antimicrobial armamentarium must be found. In this narrative review, current and emerging non-antibiotic antimicrobial strategies will be considered and the need for antimicrobial stewardship in wound care will be explained.
Journal of Wound Care;
Cooper, R. and Kirketerp-Møller, K. (2018) 'Non-antibiotic antimicrobial interventions and antimicrobial stewardship in wound care', Journal of Wound Care, 27(6), pp.355-377. DOI: 10.12968/jowc.2018.27.6.355.
Article published in Journal of Wound Care on 08 June 2018, available at: https://doi.org/10.12968/jowc.2018.27.6.355.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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