• English
    • Welsh
  • Welsh 
    • English
    • Welsh
  • Mewngofnodi
Chwilio'r safle:
  • Hafan
  • Ymchwil ym Met Caerdydd
  • Gwasanaethau Llyfrgell
  • Cysylltu â Ni
Gweld eitem 
  • Hafan DSpace
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • Gweld eitem
  • Hafan DSpace
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • Gweld eitem
JavaScript is disabled for your browser. Some features of this site may not work without it.

The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using rotational thromboelastometry: a prospective observational study

Thumbnail
Gweld/agor
Author's post-print (738.1Kb)
Awdur
Davies, Gareth R.
Lawrence, Matthew
Pillai, Suresh
Mills, Gavin
Aubrey, Robert
Thomas, Dafydd
Williams, Rhodri
Morris, Keith
Evans, Philip Adrian
Dyddiad
2017-10-02
Dyddiad derbyn
2017
Date Deposited
2019-04-30
Math
Article
Cyhoeddwr
Elsevier
ISSN
1557-8615
Metadata
Dangos cofnod eitem llawn
Crynodeb
Purpose: The study purpose was to define changes in coagulation across the sepsis spectrum using rotational thromboelastometry (ROTEM).Methods: Sepsis patients were recruited on admission to the Emergency Department and Intensive Care Units of a large teaching hospital in Wales. ROTEM markers of clot development and fibrinolysis were determined, as well as standard coagulation markers. A healthy control group matched for age and gender was also recruited (n = 44). Results: 100 patients were recruited (50 sepsis, 20 severe sepsis and 30 septic shock). Maximum clot firmness was significantly higher in the sepsis (p < 0.001) and severe sepsis (p = 0.012) groups than the healthy control (71.6 ± 4.5 and 70.4 ± 4.1 vs 64.4 respectively). In septic shock there was prolonged clot development; however, maximum clot firmness remained normal. Fibrinolytic function was significantly impaired in septic shock, which was also significantly associated with 28-day mortality (p < 0.001). Conclusions: ROTEM indicated significantly enhanced clot structural development in sepsis and severe sepsis, which could be indicative of a hypercoagulable phase. In septic shock, despite there being a prolongation of clotting pathways and impaired fibrinolysis, clot mass was comparably normal, suggestive of the development of a clot with healthy characteristics.
Cyfnodolyn/trafodion cynhadledd
Journal of Critical Care;
Dyfyniad
Davies, G.R., Lawrence, M., Pillai, S., Mills, G.M., Aubrey, R., Thomas, D., Williams, R., Morris, K. and Evans, P.A. (2018) 'The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using rotational thromboelastometry: A prospective observational study', Journal of Critical Care, 44, pp.7-11. DOI:10.1016/j.jcrc.2017.09.183.
URI
http://hdl.handle.net/10369/10464
Dynodwr Gwrthrych Digidol (DOI)
https://doi.org/10.1016/j.jcrc.2017.09.183
Disgrifiad
Article published in Journal of Critical Care on 02 October (online), available at: https://doi.org/10.1016/j.jcrc.2017.09.183.
Hawliau
https://creativecommons.org/licenses/by-nc-nd/4.0/
Nawdd
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Casgliadau
  • Health and Risk Management [403]

Eitemau perthynol

Yn dangos eitemau sy’n perthyn drwy deitl, awdur, pwnc a chrynodeb.

  • Braslun bawd

    The effect of sepsis and its inflammatory response on mechanical clot characteristics: a prospective observational study 

    Davies, Gareth R.; Pillai, Suresh; Lawrence, Matthew; Mills, Gavin M.; Aubrey, Robert; D'Silva, Lindsay; Battle, Ceri; Williams, Rhodri; Brown, Rowan; Thomas, Dafydd; Morris, Keith; Evans, Phillip Adrian (Springer, 2016-09-03)
    Purpose = Sepsis and its progression are known to have a major influence on the coagulation system. Current coagulation tests are of limited use when assessing coagulation in sepsis patients. This study aims to assess the ...
  • Braslun bawd

    The Role of Whole Blood Impedance Aggregometry and Its Utilisation in the Diagnosis and Prognosis of Patients with Systemic Inflammatory Response Syndrome and Sepsis in Acute Critical Illness 

    Davies, Gareth R.; Mills, Gavin M.; Lawrence, Matthew; Battle, Ceri; Morris, Keith; Hawkins, Karl; Williams, Phylip R.; Davidson, Simon; Thomas, Dafydd; Evans, Phillip A. (PLoS, 2014-09-30)
    Objective: To assess the prognostic and diagnostic value of whole blood impedance aggregometry in patients with sepsis and SIRS and to compare with whole blood parameters (platelet count, haemoglobin, haematocrit and white ...
  • Braslun bawd

    Surface expression of CD14, TLR4 and TLR2 and cytokine release by Monomac-6 cells in response to Lipopolysaccharide and Pam3 stimulation 

    Silas, Shefina (Cardiff Metropolitan University, 2010)
    Sepsis still remains the most common cause of death of the patients in the intensive care unit. Therefore, investigation of the mechanisms behind the recognition of bacterial structural components can be used to determine ...

Pori

Holl Dspace Met CaerdyddCymunedau a ChasgliadauYn ôl dyddiad cyhoeddiAwduronTeitlauPynciauY casgliad hwnYn ôl dyddiad cyhoeddiAwduronTeitlauPynciau

Fy Nghyfrif

Mewngofnodi

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Cysylltu â ni | Anfon adborth | Gweinyddwr