dc.contributor.author | Davies, Gareth R. | |
dc.contributor.author | Lawrence, Matthew | |
dc.contributor.author | Pillai, Suresh | |
dc.contributor.author | Mills, Gavin | |
dc.contributor.author | Aubrey, Robert | |
dc.contributor.author | Thomas, Dafydd | |
dc.contributor.author | Williams, Rhodri | |
dc.contributor.author | Morris, Keith | |
dc.contributor.author | Evans, Philip Adrian | |
dc.date.accessioned | 2019-04-30T10:29:25Z | |
dc.date.available | 2019-04-30T10:29:25Z | |
dc.date.issued | 2017-10-02 | |
dc.identifier.citation | Davies, G.R., Lawrence, M., Pillai, S., Mills, G.M., Aubrey, R., Thomas, D., Williams, R., Morris, K. and Evans, P.A. (2018) 'The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using rotational thromboelastometry: A prospective observational study', Journal of Critical Care, 44, pp.7-11. DOI:10.1016/j.jcrc.2017.09.183. | en_US |
dc.identifier.issn | 1557-8615 | |
dc.identifier.uri | http://hdl.handle.net/10369/10464 | |
dc.description | Article published in Journal of Critical Care on 02 October (online), available at: https://doi.org/10.1016/j.jcrc.2017.09.183. | en_US |
dc.description.abstract | Purpose: The study purpose was to define changes in coagulation across the sepsis spectrum using rotational thromboelastometry (ROTEM).Methods: Sepsis patients were recruited on admission to the Emergency Department and Intensive Care Units of a large teaching hospital in Wales. ROTEM markers of clot development and fibrinolysis were determined, as well as standard coagulation markers. A healthy control group matched for age and gender was also recruited (n = 44). Results: 100 patients were recruited (50 sepsis, 20 severe sepsis and 30 septic shock). Maximum clot firmness was significantly higher in the sepsis (p < 0.001) and severe sepsis (p = 0.012) groups than the healthy control (71.6 ± 4.5 and 70.4 ± 4.1 vs 64.4 respectively). In septic shock there was prolonged clot development; however, maximum clot firmness remained normal. Fibrinolytic function was significantly impaired in septic shock, which was also significantly associated with 28-day mortality (p < 0.001). Conclusions: ROTEM indicated significantly enhanced clot structural development in sepsis and severe sepsis, which could be indicative of a hypercoagulable phase. In septic shock, despite there being a prolongation of clotting pathways and impaired fibrinolysis, clot mass was comparably normal, suggestive of the development of a clot with healthy characteristics. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.relation.ispartofseries | Journal of Critical Care; | |
dc.title | The effect of sepsis and septic shock on the viscoelastic properties of clot quality and mass using rotational thromboelastometry: a prospective observational study | en_US |
dc.type | Article | en_US |
dc.identifier.doi | https://doi.org/10.1016/j.jcrc.2017.09.183 | |
dcterms.dateAccepted | 2017 | |
rioxxterms.funder | Cardiff Metropolitan University | en_US |
rioxxterms.identifier.project | Cardiff Metropolian (Internal) | en_US |
rioxxterms.version | AM | en_US |
rioxxterms.licenseref.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | en_US |
rioxxterms.licenseref.startdate | 2019-04-30 | |
dc.refexception | There was a delay in securing the final peer-reviewed text | |
dc.date.refFCD | 2019-04-30 | |
rioxxterms.funder.project | 37baf166-7129-4cd4-b6a1-507454d1372e | en_US |