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dc.contributor.authorOtto, James
dc.contributor.authorPlumb, James O.M.
dc.contributor.authorWakeham, Denis
dc.contributor.authorClissold, E.
dc.contributor.authorLoughney, Lisa
dc.contributor.authorSchmidt, W.
dc.contributor.authorMontgomery, Hugh
dc.contributor.authorGrocott, Mike
dc.contributor.authorRichards, Toby
dc.identifier.citationOtto, J.M., Plumb, J.O.M., Wakeham, D., Clissold, E., Loughney, L., Schmidt, W., Montgomery, H.E., Grocott, M.P.W. and Richards, T. (2017) 'Total haemoglobin mass, but not haemoglobin concentration, is associated with preoperative cardiopulmonary exercise testing-derived oxygen-consumption variables', BJA: British Journal of Anaesthesia, 118(5), pp.747-754. DOI: 10.1093/bja/aew445.en_US
dc.descriptionArticle published in BJA: British Journal of Anaesthesia on 15 May 2017, available at:
dc.description.abstractBackground. Cardiopulmonary exercise testing (CPET) measures peak exertional oxygen consumption (⁠V˙O2peak⁠) and that at the anaerobic threshold (⁠V˙O2 at AT, i.e. the point at which anaerobic metabolism contributes substantially to overall metabolism). Lower values are associated with excess postoperative morbidity and mortality. A reduced haemoglobin concentration ([Hb]) results from a reduction in total haemoglobin mass (tHb-mass) or an increase in plasma volume. Thus, tHb-mass might be a more useful measure of oxygen-carrying capacity and might correlate better with CPET-derived fitness measures in preoperative patients than does circulating [Hb]. Methods. Before major elective surgery, CPET was performed, and both tHb-mass (optimized carbon monoxide rebreathing method) and circulating [Hb] were determined. Results. In 42 patients (83% male), [Hb] was unrelated to V˙O2 at AT and V˙O2peak (r=0.02, P=0.89 and r=0.04, P=0.80, respectively) and explained none of the variance in either measure. In contrast, tHb-mass was related to both (r=0.661, P<0.0001 and r=0.483, P=0.001 for V˙O2 at AT and V˙O2peak⁠, respectively). The tHb-mass explained 44% of variance in V˙O2 at AT (P<0.0001) and 23% in V˙O2peak (P=0.001). Conclusions. In contrast to [Hb], tHb-mass is an important determinant of physical fitness before major elective surgery. Further studies should determine whether low tHb-mass is predictive of poor outcome and whether targeted increases in tHb-mass might thus improve outcome.en_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesBritish Journal of Anaesthesia;
dc.titleTotal haemoglobin mass, but not haemoglobin concentration, is associated with preoperative cardiopulmonary exercise testing-derived oxygen-consumption variablesen_US
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US

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