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dc.contributor.authorOtto, James
dc.contributor.authorPlumb, James O.M.
dc.contributor.authorWakeham, Denis
dc.contributor.authorClissold, E.
dc.contributor.authorLoughney, Lisa
dc.contributor.authorSchmidt, W.
dc.contributor.authorMontgomery, Hugh
dc.contributor.authorGrocott, Mike
dc.contributor.authorRichards, Toby
dc.date.accessioned2019-05-17T09:01:11Z
dc.date.available2019-05-17T09:01:11Z
dc.date.issued2017-05-15
dc.identifier.citationOtto, J.M., Plumb, J.O.M., Wakeham, D., Clissold, E., Loughney, L., Schmidt, W., Montgomery, H.E., Grocott, M.P.W. and Richards, T. (2017) 'Total haemoglobin mass, but not haemoglobin concentration, is associated with preoperative cardiopulmonary exercise testing-derived oxygen-consumption variables', BJA: British Journal of Anaesthesia, 118(5), pp.747-754. DOI: 10.1093/bja/aew445.en_US
dc.identifier.issn1471-6771
dc.identifier.urihttp://hdl.handle.net/10369/10501
dc.descriptionArticle published in BJA: British Journal of Anaesthesia on 15 May 2017, available at: https://doi.org/10.1093/bja/aew445.en_US
dc.description.abstractBackground. Cardiopulmonary exercise testing (CPET) measures peak exertional oxygen consumption (⁠V˙O2peak⁠) and that at the anaerobic threshold (⁠V˙O2 at AT, i.e. the point at which anaerobic metabolism contributes substantially to overall metabolism). Lower values are associated with excess postoperative morbidity and mortality. A reduced haemoglobin concentration ([Hb]) results from a reduction in total haemoglobin mass (tHb-mass) or an increase in plasma volume. Thus, tHb-mass might be a more useful measure of oxygen-carrying capacity and might correlate better with CPET-derived fitness measures in preoperative patients than does circulating [Hb]. Methods. Before major elective surgery, CPET was performed, and both tHb-mass (optimized carbon monoxide rebreathing method) and circulating [Hb] were determined. Results. In 42 patients (83% male), [Hb] was unrelated to V˙O2 at AT and V˙O2peak (r=0.02, P=0.89 and r=0.04, P=0.80, respectively) and explained none of the variance in either measure. In contrast, tHb-mass was related to both (r=0.661, P<0.0001 and r=0.483, P=0.001 for V˙O2 at AT and V˙O2peak⁠, respectively). The tHb-mass explained 44% of variance in V˙O2 at AT (P<0.0001) and 23% in V˙O2peak (P=0.001). Conclusions. In contrast to [Hb], tHb-mass is an important determinant of physical fitness before major elective surgery. Further studies should determine whether low tHb-mass is predictive of poor outcome and whether targeted increases in tHb-mass might thus improve outcome.en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesBritish Journal of Anaesthesia;
dc.titleTotal haemoglobin mass, but not haemoglobin concentration, is associated with preoperative cardiopulmonary exercise testing-derived oxygen-consumption variablesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1093/bja/aew445
dcterms.dateAccepted2016-12-13
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2019-05-17
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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