Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners
Pugh, Christopher J. A.
American Physiological Society
MetadataDangos cofnod eitem llawn
This study focussed on the influence of habitual endurance exercise training (i.e. committed runner or non-runner) on the regulation of muscle sympathetic nerve activity (MSNA) and arterial pressure in middle-aged (50 to 63 years, n= 23) and younger (19 to 30 years; n=23) normotensive men. Haemodynamic and neurophysiological assessments were performed at rest. Indices of vascular sympathetic baroreflex function were determined from the relationship between spontaneous changes in diastolic blood pressure (DBP) and MSNA. Large vessel arterial stiffness and left ventricular stroke volume also were measured. Paired comparisons were performed within each age-category. Mean arterial pressure and basal MSNA bursts·min-1 were not different between age-matched runners and non-runners. However, MSNA bursts·100 heartbeats-1, an index of baroreflex regulation of MSNA (vascular sympathetic baroreflex operating point) was higher for middle-aged runners (P=0.006), whereas this was not different between young runners and non-runners. The slope of the DBP-MSNA relationship (vascular sympathetic baroreflex gain) was not different between groups in either age-category. Aortic pulse wave velocity was lower for runners of both age-categories (P<0.03), although carotid β stiffness was lower only for middle-aged runners (P=0.04). For runners of both age-categories, stroke volume was larger, while heart rate was lower (both P<0.01). In conclusion, we suggest that neural remodelling and upward setting of the vascular sympathetic baroreflex compensates for cardiovascular adaptations after many years committed to endurance exercise training, presumably to maintain arterial blood pressure stability.
American Journal of Physiology-Heart and Circulatory Physiology;
Wakeham, D.J., Lord, R.N., Talbot, J.S., Lodge, F.M., Curry, B.A., Dawkins, T.G., Simpson, L.L., Shave, R.E., Pugh, C.J. and Moore, J.P. (2019) 'Upward resetting of the vascular sympathetic baroreflex in middle-aged male runners', American Journal of Physiology-Heart and Circulatory Physiology. https://doi.org/10.1152/ajpheart.00106.2019
Dynodwr Gwrthrych Digidol (DOI)https://doi.org/10.1152/ajpheart.00106.2019
Article published in American Journal of Physiology-Heart and Circulatory Physiology available at https://doi.org/10.1152/ajpheart.00106.2019
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Sport Research Groups 
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The influence of barosensory vessel mechanics on the vascular sympathetic baroreflex: Insights into ageing and blood pressure homeostasis Lord, Rachel; Wakeham, Denis; Pugh, Christopher J. A.; Simpson, Lydia; Talbot, Jack; Lodge, Freya; Curry, Bryony; Dawkins, Tony; Shave, Rob; Moore, Jonathan (American Physiological Society, 2020-08-01)Changes in the arterial baroreflex arc contribute to elevated sympathetic outflow and altered reflex control of blood pressure with human ageing. Utilizing ultrasound and sympathetic microneurography (muscle sympathetic ...
The influence of habitual exercise on central haemodynamics and peripheral blood pressure regulation in normotensive middle-aged men Wakeham, Denis (Cardiff Metropolitan University, 2020)Central (aortic) haemodynamics change markedly with age, as aortic stiffness and systolic pressure augmentation increase thereby elevating aortic blood pressure. Furthermore, the autonomic regulation of vascular sympathetic ...
Baroreflex control of sympathetic vasomotor activity and resting arterial pressure at high altitude: insight from Lowlanders and Sherpa Simpson, Lydia; Busch, Stephen; Oliver, Samuel; Ainslie, Philip; Stembridge, Mike; Steinback, Craig; Moore, Jonathan (Wiley, 2019-03-20)Exposure to high altitude (HA) is characterized by heightened muscle sympathetic neural activity (MSNA); however, the effect on arterial baroreflex control of MSNA is unknown. Furthermore, arterial baroreflex control at ...