Increased levels of soluble Receptor for Advanced Glycation End-Products (RAGE) are associated with a higher risk of mortality in frail older adults
Garcia-Garcia, Francisco Jose
Oxford University Press
MetadataShow full item record
Objective: To evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. Methods: We studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo Study of Healthy Aging and the AMI study, who were enrolled to the FRAILOMIC initiative. Multivariate Cox proportional hazards regression and Kaplan-Meier survival analysis were used to assess the relationship between baseline sRAGE and mortality. Results: During 6 years of follow-up 101 participants died (50 frail and 51 non-frail). Frail individuals who died had significantly higher sRAGE levels than those who survived (median [IQR]: 1563 [1015-2248] vs 1184 [870-1657] pg/mL, P=0.006), whilst no differences were observed in the non-frail group (1262 [1056-1554] vs 1186 [919-1551] pg/mL, P=0.19). Among frail individuals higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates (HR=2.72 per unit increment in ln-sRAGE, 95%CI 1.48-4.99, P=0.001). In contrast, in non-frail individuals sRAGE showed no association with mortality. Survival curves demonstrated that among frail individuals the incidence of death was significantly higher in the top sRAGE quartile compared to the three lower quartiles (P=0.002). Area under the ROC curve analysis demonstrated that for frail individuals, inclusion of sRAGE in the hazard model increased its predictive accuracy by ~3%. Conclusions: sRAGE is an independent predictor of mortality among frail individuals. Determination of sRAGE in frail subjects could be useful for prognostic assessment and treatment stratification.
Age and Ageing;
Article published in Age and Ageing on 18 June 2019, available at: https://doi.org/10.1093/ageing/afz073.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
The FRAILOMIC study was supported by the European Union Seventh Framework Programme under grant agreement number 305483.
The AMI project was funded by AGRICA (CAMARCA, CRCCA, CCPMA PREVOYANCE, CPCEA, AGRI PREVOYANCE), la Mutualité Sociale Agricole (MSA) de Gironde, la Caisse Centrale de la Mutualité Sociale Agricole (CCMSA).
Showing items related by title, author, subject and abstract.
Butcher, Lee; Carnicero, Jose Antonio; Peres, Karine; Colpo, Marco; Gomez-Cabrero, David; Dartigues, Jean-François; Bandinelli, Stefania; Garcia-Garcia, Francisco Jose; Manas, Leocadio Rodriguez; Erusalimsky, Jorge (Karger, 2020)Introduction: The evidence that blood levels of the soluble receptor for advanced glycation end products (sRAGE) predict mortality in people with cardiovascular diseases (CVD) is inconsistent. To clarify this matter, we ...
The effects of the dietary lipid Conjugated Linoleic Acid (CLA) and its 9:11 isomer on the expression of soluble receptors for advanced glycation end-products (sRAGE) in THP-1 Monocytic cells Davies, Rhodri (University of Wales Institute Cardiff, 2012)This study aimed to investigate the hypothesis that the dietary lipid Conjugated Linoleic Acid (CLA) and its 9:11 isomer are capable of inducing the expression of the soluble variant of the Receptor for Advance Glycation ...
Drew, Ellie (Cardiff Metropolitan University, 2017-06-01)The binding of Advanced Glycation Endproducts (AGEs) to the Receptor for Advanced Glycation Endproducts (RAGE) has been implicated in the pathogenesis of many inflammatory disorders. The RAGE mediated pathway leads to ...