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dc.contributor.authorButcher, Lee
dc.contributor.authorCarnicero, Jose
dc.contributor.authorGomez-Cabrero, David
dc.contributor.authorDartigues, Jean-Francois
dc.contributor.authorPeres, Karine
dc.contributor.authorGarcia-Garcia, Francisco Jose
dc.contributor.authorRodriguez-Mañas, Leocadio
dc.contributor.authorErusalimsky, Jorge
dc.date.accessioned2019-05-29T08:26:04Z
dc.date.available2019-05-29T08:26:04Z
dc.date.issued2019-06-18
dc.identifier.issn1468-2834
dc.identifier.urihttp://hdl.handle.net/10369/10534
dc.descriptionArticle published in Age and Ageing on 18 June 2019, available at: https://doi.org/10.1093/ageing/afz073.en_US
dc.description.abstractObjective: To evaluate the relationship between serum levels of the soluble Receptor for Advanced Glycation End-products (sRAGE) and mortality in frail and non-frail older adults. Methods: We studied 691 subjects (141 frail and 550 non-frail) with a median age of 75 years from two population-based cohorts, the Toledo Study of Healthy Aging and the AMI study, who were enrolled to the FRAILOMIC initiative. Multivariate Cox proportional hazards regression and Kaplan-Meier survival analysis were used to assess the relationship between baseline sRAGE and mortality. Results: During 6 years of follow-up 101 participants died (50 frail and 51 non-frail). Frail individuals who died had significantly higher sRAGE levels than those who survived (median [IQR]: 1563 [1015-2248] vs 1184 [870-1657] pg/mL, P=0.006), whilst no differences were observed in the non-frail group (1262 [1056-1554] vs 1186 [919-1551] pg/mL, P=0.19). Among frail individuals higher sRAGE levels were associated with an increased risk of death after adjustment for relevant covariates (HR=2.72 per unit increment in ln-sRAGE, 95%CI 1.48-4.99, P=0.001). In contrast, in non-frail individuals sRAGE showed no association with mortality. Survival curves demonstrated that among frail individuals the incidence of death was significantly higher in the top sRAGE quartile compared to the three lower quartiles (P=0.002). Area under the ROC curve analysis demonstrated that for frail individuals, inclusion of sRAGE in the hazard model increased its predictive accuracy by ~3%. Conclusions: sRAGE is an independent predictor of mortality among frail individuals. Determination of sRAGE in frail subjects could be useful for prognostic assessment and treatment stratification.en_US
dc.description.sponsorshipThe FRAILOMIC study was supported by the European Union Seventh Framework Programme under grant agreement number 305483.en_US
dc.description.sponsorshipThe AMI project was funded by AGRICA (CAMARCA, CRCCA, CCPMA PREVOYANCE, CPCEA, AGRI PREVOYANCE), la Mutualité Sociale Agricole (MSA) de Gironde, la Caisse Centrale de la Mutualité Sociale Agricole (CCMSA).en_US
dc.language.isoenen_US
dc.publisherOxford University Pressen_US
dc.relation.ispartofseriesAge and Ageing;
dc.titleIncreased levels of soluble Receptor for Advanced Glycation End-Products (RAGE) are associated with a higher risk of mortality in frail older adultsen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1093/ageing/afz073
dcterms.dateAccepted2019-05-24
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-05-29
rioxxterms.freetoread.startdate2020-06-18
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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