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dc.contributor.authorStembridge, Mike
dc.contributor.authorWilliams, Alexandra M.
dc.contributor.authorGasho, Christopher
dc.contributor.authorDawkins, Tony
dc.contributor.authorDrane, Aimee L.
dc.contributor.authorVillafuerte, Francisco C.
dc.contributor.authorLevine, Benjamin D.
dc.contributor.authorShave, Rob
dc.contributor.authorAinslie, Philip N.
dc.date.accessioned2019-07-18T13:43:46Z
dc.date.available2019-07-18T13:43:46Z
dc.date.issued2019-07-29
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/47786/16177.full.pdf
dc.identifier.issn0027-8424
dc.identifier.issn1091-6490 (online)
dc.identifier.urihttp://hdl.handle.net/10369/10628
dc.descriptionArticle published in Proceedings of the National Academy of Sciences on 29 July 2019, available open access at: https://doi.org/10.1073/pnas.1909002116.en_US
dc.description.abstractIn contrast to Andean natives, high altitude Tibetans present with a lower hemoglobin concentration that correlates with reproductive success and exercise capacity. Decades of physiological and genomic research have assumed that the lower hemoglobin concentration in Himalayan natives results from a blunted erythropoietic response to hypoxia (i.e. no increase in total hemoglobin mass). In contrast, herein we test the hypothesis that the lower hemoglobin concentration is the result of greater plasma volume, rather than an absence of increased hemoglobin production. We assessed hemoglobin mass, plasma volume and blood volume in lowlanders at sea level, lowlanders acclimatized to high altitude, Himalayan Sherpa and Andean Quechua, and explored the functional relevance of volumetric hematological measures to exercise capacity. Hemoglobin mass was highest in Andeans, but also elevated in Sherpa compared to lowlanders. Sherpa demonstrated a larger plasma volume than Andeans, resulting in a comparable total blood volume at a lower hemoglobin concentration. Hemoglobin mass was positively related to exercise capacity in lowlanders at sea level and Sherpa at high altitude, but not in Andean natives. Collectively, our findings demonstrate a unique adaptation in Sherpa that reorientates attention away from hemoglobin concentration and towards a paradigm where hemoglobin mass and plasma volume may represent phenotypes with adaptive significance at high altitude.en_US
dc.language.isoenen_US
dc.publisherNational Academy of Sciencesen_US
dc.relation.ispartofseriesProceedings of the National Academy of Sciences;
dc.subjectaltitudeen_US
dc.subjecthypoxiaen_US
dc.subjecthemoglobinen_US
dc.subjectnatural selectionen_US
dc.titleThe overlooked significance of plasma volume for successful adaptation to high altitude in Sherpa and Andean nativesen_US
dc.typeArticleen_US
dcterms.dateAccepted2019-07-10
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1073/pnas.1909002116
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.publicationdate2019-07-29
dc.date.refFCD2019-07-18
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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