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dc.contributor.authorBadawy, Abdulla
dc.contributor.authorBano, Samina
dc.date.accessioned2019-08-01T08:51:02Z
dc.date.available2019-08-01T08:51:02Z
dc.date.issued2016-08-11
dc.identifier.citationBadawy, A.A.B. and Bano, S. (2016) 'Tryptophan metabolism in rat liver after administration of tryptophan, kynurenine metabolites, and kynureninase inhibitors', International Journal of Tryptophan Research, 9, pp.IJTR-S38190. DOI: 10.4137/IJTR.S38190.en_US
dc.identifier.issn1178-6469
dc.identifier.urihttp://hdl.handle.net/10369/10663
dc.descriptionArticle published in International Journal of Tryptophan Research on 11 August 2016, available open access at: https://doi.org/10.4137/IJTR.S38190.en_US
dc.description.abstractRat liver tryptophan (Trp), kynurenine pathway metabolites, and enzymes deduced from product/substrate ratios were assessed following acute and/or chronic administration of kynurenic acid (KA), 3-hydroxykynurenine (3-HK), 3-hydroxyanthranilic acid (3-HAA), Trp, and the kynureninase inhibitors benserazide (BSZ) and carbidopa (CBD). KA activated Trp 2,3-dioxygenase (TDO), possibly by increasing liver 3-HAA, but inhibited kynurenine aminotransferase (KAT) and kynureninase activities with 3-HK as substrate. 3-HK inhibited kynureninase activity from 3-HK. 3-HAA stimulated TDO, but inhibited kynureninase activity from K and 3-HK. Trp (50 mg/kg) increased kynurenine metabolite concentrations and KAT from K, and exerted a temporary stimulation of TDO. The kynureninase inhibitors BSZ and CBD also inhibited KAT, but stimulated TDO. BSZ abolished or strongly inhibited the Trp-induced increases in liver Trp and kynurenine metabolites. The potential effects of these changes in conditions of immune activation, schizophrenia, and other disease states are discussed.en_US
dc.language.isoenen_US
dc.publisherSAGEen_US
dc.relation.ispartofseriesInternational Journal of Tryptophan Research;
dc.titleTryptophan Metabolism in Rat Liver after Administration of Tryptophan, Kynurenine Metabolites, and Kynureninase Inhibitorsen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.4137/IJTR.S38190
dcterms.dateAccepted2016-07-19
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2019-08-01
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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