The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries
View/ open
Author
Burton, Hanna
Espino, Daniel
Date
2019-01-23Acceptance date
2019-01-01
Type
Article
Publisher
Hindawi
ISSN
1754-2103
Metadata
Show full item recordAbstract
Background. Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for example, due to a rupture of an artery. Methods. The porcine left anterior descending (LAD) coronary arteries were dissected ex vivo. Mechanical overloading was applied to the arteries in the longitudinal direction to simulate extreme physiological loading. Surface roughness was calculated from three-dimensional reconstructed images. Surface roughness was measured before and after damage and after chemical processing to dehydrate tissue specimens. Results. Control specimens confirmed that dehydration alone results in an increase of surface roughness in the circumferential direction only. No variation was noted between the hydrated healthy and damaged specimens, in both the longitudinal ( and ) and circumferential ( and ) directions. After dehydration, an increase in surface roughness was noted for damaged specimens in both the longitudinal () and circumferential () directions. Conclusions. Mechanical overloading applied in the longitudinal direction did not significantly affect surface roughness. However, when combined with chemical processing, a significant increase in surface roughness was noted in both the circumferential and longitudinal directions. Mechanical overloading causes damage to the internal constituents of the arteries, which is significantly noticeable after dehydration of tissue.
Journal/conference proceeding
Applied Bionics and Biomechanics;
Citation
Burton, H.E. and Espino, D.M. (2019) 'The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries', Applied Bionics and Biomechanics. DOI: 10.1155/2019/2784172.
Description
Article published in Applied Bionics and Biomechanics on 23 January 2019, available open access at: https://doi.org/10.1155/2019/2784172.
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
HEB was funded by an Engineering and Physical Sciences Research Council scholarship (M114612B). The materials and testing equipment used in this study was funded by an Arthritis Research UK grant (H0671). This study was partly funded by an Innovation and Research Award from the Institute of Physics and Engineering in Medicine.
Collections
Related items
Showing items related by title, author, subject and abstract.
-
Effects of freezing, fixation and dehydration on surface roughness properties of porcine left anterior descending coronary arteries
Burton, Hanna; Williams, Richard; Espino, Daniel (Elsevier, 2017-06-22)Background To allow measurements of surface roughness to be made of coronary arteries using various imaging techniques, chemical processing, such as fixation and dehydration, is commonly used. Standard protocols suggest ... -
Dynamic viscoelasticity and surface properties of porcine left anterior descending coronary arteries
Burton, Hanna; Freij, Jenny M.; Espino, Daniel M. (Springer, 2016-12-12)The aim of this study was, for the first time, to measure and compare quantitatively the viscoelastic properties and surface roughness of coronary arteries. Porcine left anterior descending coronary arteries were dissected ... -
Multiscale three-dimensional surface reconstruction and surface roughness of porcine left anterior descending coronary arteries
Burton, Hanna; Cullinan, Rachael; Jiang, Kyle; Espino, Daniel M. (Royal Society, 2019-09-11)The aim of this study was to investigate the multiscale surface roughness characteristics of coronary arteries, to aid in the development of novel biomaterials and bioinspired medical devices. Porcine left anterior descending ...