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dc.contributor.authorBurton, Hanna
dc.contributor.authorEspino, Daniel
dc.date.accessioned2019-08-06T09:28:03Z
dc.date.available2019-08-06T09:28:03Z
dc.date.issued2019-01-23
dc.identifier.citationBurton, H.E. and Espino, D.M. (2019) 'The Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteries', Applied Bionics and Biomechanics. DOI: 10.1155/2019/2784172.en_US
dc.identifier.issn1754-2103
dc.identifier.urihttp://hdl.handle.net/10369/10687
dc.descriptionArticle published in Applied Bionics and Biomechanics on 23 January 2019, available open access at: https://doi.org/10.1155/2019/2784172.en_US
dc.description.abstractBackground. Surface roughness can be used to identify disease within biological tissues. Quantifying surface roughness in the coronary arteries aids in developing treatments for coronary heart disease. This study investigates the effect of extreme physiological loading on surface roughness, for example, due to a rupture of an artery. Methods. The porcine left anterior descending (LAD) coronary arteries were dissected ex vivo. Mechanical overloading was applied to the arteries in the longitudinal direction to simulate extreme physiological loading. Surface roughness was calculated from three-dimensional reconstructed images. Surface roughness was measured before and after damage and after chemical processing to dehydrate tissue specimens. Results. Control specimens confirmed that dehydration alone results in an increase of surface roughness in the circumferential direction only. No variation was noted between the hydrated healthy and damaged specimens, in both the longitudinal ( and ) and circumferential ( and ) directions. After dehydration, an increase in surface roughness was noted for damaged specimens in both the longitudinal () and circumferential () directions. Conclusions. Mechanical overloading applied in the longitudinal direction did not significantly affect surface roughness. However, when combined with chemical processing, a significant increase in surface roughness was noted in both the circumferential and longitudinal directions. Mechanical overloading causes damage to the internal constituents of the arteries, which is significantly noticeable after dehydration of tissue.en_US
dc.description.sponsorshipHEB was funded by an Engineering and Physical Sciences Research Council scholarship (M114612B). The materials and testing equipment used in this study was funded by an Arthritis Research UK grant (H0671). This study was partly funded by an Innovation and Research Award from the Institute of Physics and Engineering in Medicine.
dc.language.isoenen_US
dc.publisherHindawien_US
dc.relation.ispartofseriesApplied Bionics and Biomechanics;
dc.titleThe Effect of Mechanical Overloading on Surface Roughness of the Coronary Arteriesen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1155/2019/2784172
dcterms.dateAccepted2019-01-01
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-08-06
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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