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dc.contributor.authorHowe, Connor
dc.contributor.authorAinslie, Philip
dc.contributor.authorTremblay, Joshua
dc.contributor.authorCarter, Howard
dc.contributor.authorPatrician, Alex
dc.contributor.authorStembridge, Mike
dc.contributor.authorWilliams, Alexandra
dc.contributor.authorDrane, Aimee L.
dc.contributor.authorDelorme, Eric
dc.contributor.authorRieger, Mathew
dc.contributor.authorTymko, Michael
dc.contributor.authorGasho, Chris
dc.contributor.authorSantoro, Antoinette
dc.contributor.authorMacleod, David
dc.contributor.authorHoiland, Ryan
dc.date.accessioned2019-08-21T08:47:57Z
dc.date.available2019-08-21T08:47:57Z
dc.date.issued2019-08-13
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/42007/2988_1_merged_1563236337%20(1).pdf
dc.identifier.citationHowe, C.A., Ainslie, P.N., Tremblay, J.C., Carter, H.H., Patrician, A., Stembridge, M., Williams, A., Drane, A.L., Delorme, E., Rieger, M.G. and Tymko, M.M. (2019) 'UBC‐Nepal Expedition: Haemoconcentration underlies the reductions in cerebral blood flow observed during acclimatization to high‐altitude', Experimental Physiology. DOI: 10.1113/EP087663.en_US
dc.identifier.issn1469-445X
dc.identifier.urihttp://hdl.handle.net/10369/10698
dc.descriptionArticle published in Experimental Physiology on 13 August 2019 (online), available at: https://doi.org/10.1113/EP087663.en_US
dc.description.abstractAt high‐altitude, increases in haematocrit (Hct) are achieved through altitude‐induced diuresis and erythropoiesis, both of which result in increased arterial oxygen content (CaO2). Given the impact alterations in Hct have on CaO2, haemoconcentration has been hypothesized to partly mediate the attenuation of the initial elevation in cerebral blood flow (CBF) at high‐altitude. To test this hypothesis, healthy males (n = 13) ascended to 5050 m over nine days without the aid of prophylactic acclimatization medications. Following one‐week of acclimatization at 5050 m, participants were haemodiluted by rapid saline infusion (2.10 ± 0.28 L) to return Hct towards pre‐acclimatized levels. Arterial blood gases, Hct, global CBF (duplex ultrasound), and haemodynamic variables were measured following initial arrival to 5050 m, and after one‐week of acclimatization at high‐altitude, prior to and following the haemodilution protocol. Following one‐week at 5050 m, Hct increased from 42.5 ± 2.5 to 49.6 ± 2.5% (P < 0.001), and was subsequently reduced to 45.6 ± 2.3% (P < 0.001) following haemodilution. Global CBF decreased from 844 ± 160 to 619 ± 136 ml mi−1 n (P = 0.033) following one‐week of acclimatization and increased to 714 ± 204 ml mi−1n (P = 0.045) following haemodilution. Despite the significant changes in Hct, and thus CaO2, cerebral oxygen delivery was unchanged at all time points. Furthermore, these observations occurred in the absence of any changes in mean arterial blood pressure, cardiac output, arterial blood pH, or oxygen saturation pre‐ and post‐haemodilution. These data highlight the influence of Hct in the regulation of CBF and are the first to demonstrate experimentally that haemoconcentration contributes to the reduction in CBF during acclimatization to altitude.en_US
dc.description.sponsorshipCanada Research Chairs (Chaires de recherche du Canada): Philip N Ainslie,F11-02423en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesExperimental Physiology;
dc.titleUBC-Nepal Expedition: Haemoconcentration underlies the reductions in cerebralblood flow observed during acclimatization to high-altitudeen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dcterms.dateAccepted2019-08-13
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1113/EP087663
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.licenseref.startdate2019-08-21
rioxxterms.publicationdate2019-08-13
dc.date.refFCD2019-08-21
rioxxterms.freetoread.startdate2020-08-13
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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