The role of vascular adaptation in determining systolic BP in young adults
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Background: Two individuals can have a similar pulse pressure (PP)but very different levels of systolic blood pressure(SBP),although the underlying mechanisms have not been described. We hypothesised that,for a given level of PP, differences in SBP relate to peripheral vascular resistance (PVR) and we tested this hypothesis in a large cohort of healthy young adults. Methods and Results: Demographic, biochemical and haemodynamic data from 3103 subjects were available for the current analyses.In both males and females, for a given level of PP, higher SBP was associated with significantly higher body weight, body mass index, heart rate and PVR (P<0.05 versus those with lower BP for all comparisons). Moreover, stratifying individuals by tertiles of PP and PVR revealed a stepwise increase in SBP from the lowest to highest tertiles for each variable, with the highest SBP occurring in those in the highest tertile of both PPnand PVRn(P<0.001 for overall trend for both sexes). PVR was also increased with increasing tertile of minimum forearm vascular resistance, in both males (P=0.002)and females (P=0.03). Conclusion: Increased PVR, mediated in part through altered resistance vessel structure,strongly associates with the elevation of SBP for a given level of PP in young adults. An impaired ability to adapt PVR appropriately to a given level of PP may be an important mechanism underlying elevated SBP in young adults.
Journal of the American Heart Association;
Article accepted for publication in Journal of the American Heart Association.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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