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dc.contributor.authorCai, Y.
dc.contributor.authorLi, J.
dc.contributor.authorChen, Y.
dc.contributor.authorChen, W.
dc.contributor.authorDang, C.
dc.contributor.authorZhao, Fei
dc.contributor.authorLi, W.
dc.contributor.authorChen, G.
dc.contributor.authorChen, S.
dc.contributor.authorLiang, M.
dc.contributor.authorZheng, Y.
dc.date.accessioned2019-09-23T13:52:04Z
dc.date.available2019-09-23T13:52:04Z
dc.date.issued2019-08-14
dc.identifier.citationCai, Y., Li, J., Chen, Y., Chen, W., Dang, C., Zhao, F., Li, W., Chen, G., Chen, S., Liang, M. and Zheng, Y. (2019) 'Inhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss with Tinnitus Based on Resting-state EEG', Frontiers in Neuroscience, 13, p.851. https://doi.org/10.3389/fnins.2019.00851en_US
dc.identifier.issn1662-4548
dc.identifier.issn1662-453X (online)
dc.identifier.urihttp://hdl.handle.net/10369/10733
dc.descriptionArticle published in Frontiers in Neuroscience available open access at https://doi.org/10.3389/fnins.2019.00851en_US
dc.description.abstractThis study aimed to identify the mechanism behind idiopathic sudden sensorineural hearing loss (ISSNHL) in patients with tinnitus by investigating aberrant activity in areas of the brain and functional connectivity. High-density electroencephalography (EEG) was used to investigate central nervous changes in 25 ISSNHL subjects and 27 healthy controls. ISSNHL subjects had significantly reduced activity in the left frontal lobe at the alpha 2 frequency band compared with controls. Linear lagged connectivity and lagged coherence analysis showed significantly reduced functional connectivity between the temporal gyrus and supramarginal gyrus at the gamma 2 frequency band in the ISSNHL group. Additionally, a significantly reduced functional connectivity was found between the central cingulate gyrus and frontal lobe under lagged phase synchronization analysis. These results strongly indicate inhibition of brain area activity and change in functional connectivity in ISSNHL with tinnitus patients.en_US
dc.description.sponsorshipThis study was funded by the National Natural Science Foundation of China (Grant Nos. 81600808, 81570935, and 31400874), Natural Science Foundation of Guangdong Province (Grant No. 2016A030313318), High-level University Construction of Guangzhou Medical University of China (Grant No. B185004187), and Guangzhou Science and Technology Programme livelihood projects (2014Y2-00511).en_US
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofseriesFrontiers in Neuroscience;
dc.titleInhibition of Brain Area and Functional Connectivity in Idiopathic Sudden Sensorineural Hearing Loss With Tinnitus, Based on Resting-State EEGen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3389/fnins.2019.00851
dcterms.dateAccepted2019-07-30
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-09-23


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