• English
    • Welsh
  • English 
    • English
    • Welsh
  • Login
Search DSpace:
  • Home
  • Research at Cardiff Met
  • Library Services
  • Contact Us
View item 
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
  • DSpace home
  • Cardiff School of Sport and Health Sciences
  • Health and Risk Management
  • View item
JavaScript is disabled for your browser. Some features of this site may not work without it.

A Functional Magnetic Resonance Imaging Study to Investigate the Utility of a Picture Imagination Task in Investigating Neural Responses in Patients with Chronic Musculoskeletal Pain to Daily Physical Activity Photographs

Thumbnail
Author
Taylor, A.M.
Harris, A.D.
Varnava, A.
Phillips, Rhiannon
Taylor, J.O.
Hughes, O.
Wilkes, A.R.
Hall, J.E.
Wise, R.G.
Date
2015-10-23
Acceptance date
2015
Type
Article
Publisher
Public Library of Science
ISSN
1932-6203
Metadata
Show full item record
Abstract
Pain-related anxiety and fear are associated with increased difficulties in attention, increased awareness of pain, impaired disengagement from pain, and can moderate the effects of attentional coping attempts. Accurately assessing the direct impact of pain-related anxiety and fear on pain behavior has proved difficult. Studies have demonstrated no or limited influence of pain-related fear and anxiety on behavior but this may be due to inherent problems with the scales used. Neuroimaging has improved the understanding of neural processes underlying the factors that influence pain perception. This study aimed to establish if a Picture and Imagination Task (PIT), largely developed from the Photographs of Daily Activity (PHODA) assessment tool, could help explore how people living with chronic pain process information about daily activities. Blood oxygenation level dependent (BOLD) functional magnetic resonance imaging (fMRI) was used to compare brain responses in patients with chronic musculoskeletal pain (CMSKP) (n = 15) and healthy controls (n = 15). Subjects were asked to imagine how they would feel mentally and physically if asked to perform daily activities illustrated in PIT. The results found that a number of regions involved in pain processing saw increased BOLD activation in patients compared with controls when undertaking the task and included the insula, anterior cingulate cortex, thalamus and inferior and superior parietal cortices. Similarly, increased BOLD responses in patients compared to controls in the frontal pole, paracingulate and the supplementary motor cortex may be suggestive of a memory component to the responses The amygdala, orbitofrontal cortex, substantia nigra/ventral tegmentum, putamen, thalamus, pallidum, inferior parietal (supramarginal and angular gyrus) and cingulate cortex were also seen to have greater differences in BOLD signal changes in patients compared with controls and many of these regions are also associated with general phobic responses. Therefore, we suggest that PIT is a useful task to explore pain- and movement-related anxiety and fear in fMRI studies. Regions in the Default Mode Network remained active or were less deactivated during the PIT task in patients with CMSKP compared to healthy controls supporting the contention that the DMN is abnormal in patients with CMSKP.
Journal/conference proceeding
PLoS One;
Citation
Taylor, A.M., Harris, A.D., Varnava, A., Phillips, R., Taylor, J.O., Hughes, O., Wilkes, A.R., Hall, J.E. and Wise, R.G. (2015) 'A functional magnetic resonance imaging study to investigate the utility of a picture imagination task in investigating neural responses in patients with chronic musculoskeletal pain to daily physical activity photographs', PloS one, 10(10), p.e0141133.
URI
http://hdl.handle.net/10369/10756
DOI
https://doi.org/10.1371/journal.pone.0141133
Description
Article published in PLoS One available open access at https://doi.org/10.1371/journal.pone.0141133
Collections
  • Health and Risk Management [173]

Related items

Showing items related by title, author, subject and abstract.

  • Thumbnail

    Neural responses to a modified Stroop paradigm in patients with complex chronic musculoskeletal pain compared to matched controls: an experimental functional magnetic resonance imaging study 

    Taylor, A.M.; Harris, A.D.; Varnava, A.; Phillips, Rhiannon; Hughes, O.; Wilkes, A.R.; Hall, J.E.; Wise, R.G. (BMC (Springer Nature), 2016-02-01)
    Background Chronic musculoskeletal pain (CMSKP) is attentionally demanding, complex and multi-factorial; neuroimaging research in the population seen in pain clinics is sparse. A better understanding of the neural activity ...
  • Thumbnail

    The development of a differential assay for the determination of ataxia-telangiectasia heterozygosity in human subjects 

    Savoury, Melanie (Cardiff Metropolitan University, 2008)
    Ataxia-telagiectasia (A-T) patients exhibit increased sensitivity to ionising radiation and also demonstrate a higher than normal risk of developing cancer. Heterozygote phenotypes exhibit intermediate levels of radiation ...
  • Thumbnail

    Genome-wide association study identifies SESTD1 as a novel risk gene for lithium-responsive bipolar disorder 

    Song, J.; Bergen, S.E.; Di Florio, A.; Karlsson, R.; Charney, A.; Ruderfer, D. M.; Stahl, E. A.; Chambert, K. D.; Moran, J. L.; Gordon-Smith, K.; Forty, L.; Green, Elaine (Springer Nature, 2015-10-27)
    Lithium is the mainstay prophylactic treatment for bipolar disorder (BD), but treatment response varies considerably across individuals. Patients who respond well to lithium treatment might represent a relatively homogeneous ...

Browse

DSpace at Cardiff MetCommunities & CollectionsBy issue dateAuthorsTitlesSubjectsThis collectionBy issue dateAuthorsTitlesSubjects

My Account

Login

Statistics

Most Popular ItemsStatistics by CountryMost Popular Authors

DSpace software copyright © 2002-2015  DuraSpace
Contact us | Send feedback | Administrator