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Age‐related changes to cardiac systolic and diastolic function during whole‐body passive hyperthermia

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Author
Lucas, Rebekah
Sarma, Satyam
Schadler, Zachary
Pearson, James
Crandall, Craig
Date
2015-01-15
Acceptance date
2015-01-13
Type
Article
Publisher
Wiley
ISSN
1469-445X
Metadata
Show full item record
Abstract
The effect of ageing on hyperthermia‐induced changes in cardiac function is unknown. This study tested the hypothesis that hyperthermia‐induced changes in left ventricular systolic and diastolic function are attenuated in older adults when compared with young adults. Eight older (71 ± 5 years old) and eight young adults (29 ± 5 years old), matched for sex, physical activity and body mass index, underwent whole‐body passive hyperthermia. Mean arterial pressure (Finometer Pro), heart rate, forearm vascular conductance (venous occlusion plethysmography) and echocardiographic indices of diastolic and systolic function were measured during a normothermic supine period and again after an increase in internal temperature of ∼1.0 °C. Hyperthermia decreased mean arterial pressure and left ventricular end‐diastolic volumes and increased heart rate to a similar extent in both groups (P > 0.05). Ageing did not alter the magnitude of hyperthermia‐induced changes in indices of systolic (lateral mitral annular S′ velocity) or diastolic function (lateral mitral annular E′ velocity, peak early diastolic filling and isovolumic relaxation time; P > 0.05). However, with hyperthermia the global longitudinal systolic strain increased in the older group, but was unchanged in the young group (P = 0.03). Also, older adults were unable to augment late diastolic ventricular filling [i.e. E/A ratio and A/(A + E) ratio] during hyperthermia, unlike the young (P < 0.05). These findings indicate that older adults depend on a greater systolic contribution (global longitudinal systolic strain) to meet hyperthermic demand and that the atrial contribution to diastolic filling was not further augmented in older adults when compared with young adults.
Journal/conference proceeding
Experimental Physiology;
Citation
Lucas, R.A., Sarma, S., Schlader, Z.J., Pearson, J. and Crandall, C.G. (2015) 'Age‐related changes to cardiac systolic and diastolic function during whole‐body passive hyperthermia', Experimental Physiology, 100(4), pp.422-434. DOI: 10.1113/expphysiol.2014.083014.
URI
http://hdl.handle.net/10369/10796
DOI
https://doi.org/10.1113/expphysiol.2014.083014
Description
Article published in Experimental Physiology on 15 January 2015, freely available at: https://doi.org/10.1113/expphysiol.2014.083014.
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
National Institutes of Health – National Heart, Lung, and Blood Institute. Grant Number: HL61388
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