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dc.contributor.authorLucas, Rebekah
dc.contributor.authorSarma, Satyam
dc.contributor.authorSchadler, Zachary
dc.contributor.authorPearson, James
dc.contributor.authorCrandall, Craig
dc.identifier.citationLucas, R.A., Sarma, S., Schlader, Z.J., Pearson, J. and Crandall, C.G. (2015) 'Age‐related changes to cardiac systolic and diastolic function during whole‐body passive hyperthermia', Experimental Physiology, 100(4), pp.422-434. DOI: 10.1113/expphysiol.2014.083014.en_US
dc.descriptionArticle published in Experimental Physiology on 15 January 2015, freely available at:
dc.description.abstractThe effect of ageing on hyperthermia‐induced changes in cardiac function is unknown. This study tested the hypothesis that hyperthermia‐induced changes in left ventricular systolic and diastolic function are attenuated in older adults when compared with young adults. Eight older (71 ± 5 years old) and eight young adults (29 ± 5 years old), matched for sex, physical activity and body mass index, underwent whole‐body passive hyperthermia. Mean arterial pressure (Finometer Pro), heart rate, forearm vascular conductance (venous occlusion plethysmography) and echocardiographic indices of diastolic and systolic function were measured during a normothermic supine period and again after an increase in internal temperature of ∼1.0 °C. Hyperthermia decreased mean arterial pressure and left ventricular end‐diastolic volumes and increased heart rate to a similar extent in both groups (P > 0.05). Ageing did not alter the magnitude of hyperthermia‐induced changes in indices of systolic (lateral mitral annular S′ velocity) or diastolic function (lateral mitral annular E′ velocity, peak early diastolic filling and isovolumic relaxation time; P > 0.05). However, with hyperthermia the global longitudinal systolic strain increased in the older group, but was unchanged in the young group (P = 0.03). Also, older adults were unable to augment late diastolic ventricular filling [i.e. E/A ratio and A/(A + E) ratio] during hyperthermia, unlike the young (P < 0.05). These findings indicate that older adults depend on a greater systolic contribution (global longitudinal systolic strain) to meet hyperthermic demand and that the atrial contribution to diastolic filling was not further augmented in older adults when compared with young adults.en_US
dc.description.sponsorshipNational Institutes of Health – National Heart, Lung, and Blood Institute. Grant Number: HL61388en_US
dc.relation.ispartofseriesExperimental Physiology;
dc.titleAge‐related changes to cardiac systolic and diastolic function during whole‐body passive hyperthermiaen_US
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US

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