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Global REACH 2018: The influence of acute and chronic hypoxia on cerebral haemodynamics and related functional outcomes during cold and heat stress

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Author
Gibbons, Travis
Tymko, Michael
Thomas, Kate
Wilson, Luke
Stembridge, Mike
Caldwell, Hannah
Howe, Connor
Hoiland, Ryan
Akerman, Ashley
Dawkins, Tony
Patrician, Alexander
Coombs, Geoff
Gasho, Chris
Stacey, Benjamin
Ainslie, Philip
Cotter, James D.
Date
2019-11-07
Acceptance date
2019-10-28
Date Deposited
2019-10-29
Type
Article
acceptedVersion
Publisher
Wiley
ISSN
1469-7793
Metadata
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Abstract
Real-world settings are composed of multiple environmental stressors, yet the majority of research in environmental physiology investigates these stressors in isolation. The brain is central in both behavioural and physiological responses to threatening stimuli and, given its tight metabolic and haemodynamic requirements, is particularly susceptible to environmental stress. We measured cerebral blood flow (CBF, duplex ultrasound), cerebral oxygen delivery (CDO2), oesophageal temperature, and arterial blood gases during exposure to three commonly experienced environmental stressors –heat, cold and hypoxia –in isolation, and in combination. Twelve healthy male subjects (27±11 years) underwent core cooling by 1.0ºC and core heating by 1.5ºC in randomized order at sea-level; acute hypoxia (PetO2= 50mmHg) was imposed at baseline and at each thermal extreme. Core cooling and heating protocols were repeated after 16±4 days residing at 4330m to investigate any interactions with high altitude acclimatization. Cold stress decreased CBF by 20–30% and CDO2 by 12–19%(both p<0.01)irrespective of altitude, whereas heating did not reliably change either CBF or CDO2(both p>0.08). The increases in CBF with acute hypoxia during thermal stress were appropriate to maintain CDO2 at normothermic, normoxic values. Reaction time was faster and slower by 6-9%with heating and cooling, respectively(both p<0.01), but central (brain) processes were not impaired by any combination of environmental stressors. These findings highlight the powerful influence of core cooling in reducing CDO2. Despite these large reductions in CDO2 with cold stress, gross indices of cognition remained stable.
Journal/conference proceeding
Journal of Physiology;
Citation
Gibbons, T.D., Tymko, M.M., Thomas, K.N., Wilson, L.C., Stembridge, M., Caldwell, H.G., Howe, C.A., Hoiland, R.L., Akerman, A.P., Dawkins, T.G. and Patrician, A. (2019) 'Global REACH 2018: The influence of acute and chronic hypoxia on cerebral haemodynamics and related functional outcomes during cold and heat stress', Journal of Physiology. DOI: 10.1113/JP278917.
URI
http://hdl.handle.net/10369/10801
DOI
https://doi.org/10.1113/JP278917
Description
Article published in Journal of Physiology on 07 November 2019, available at: https://doi.org/10.1113/JP278917.
Rights
http://www.rioxx.net/licenses/all-rights-reserved
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Gouvernement du Canada | Natural Sciences and Engineering ResearchCouncil of Canada (Conseil de Recherches en Sciences Naturelles et en Génie duCanada)
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