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dc.contributor.authorDavies, Gareth R.
dc.contributor.authorMills, Gavin M.
dc.contributor.authorLawrence, Matthew
dc.contributor.authorBattle, Ceri
dc.contributor.authorMorris, Keith
dc.contributor.authorHawkins, Karl
dc.contributor.authorWilliams, Phylip R.
dc.contributor.authorDavidson, Simon
dc.contributor.authorThomas, Dafydd
dc.contributor.authorEvans, Phillip A.
dc.date.accessioned2019-11-25T15:27:22Z
dc.date.available2019-11-25T15:27:22Z
dc.date.issued2014-09-30
dc.identifier.citationDavies, G.R., Mills, G.M., Lawrence, M., Battle, C., Morris, K., Hawkins, K., Williams, P.R., Davidson, S., Thomas, D. and Evans, P.A. (2014) 'The role of whole blood impedance aggregometry and its utilisation in the diagnosis and prognosis of patients with systemic inflammatory response syndrome and sepsis in acute critical illness', PLoS One, 9(9), p.e108589. DOI: 10.1371/journal.pone.0108589.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/10369/10861
dc.descriptionArticle published in PLoS ONE on 30 September 2014, available open access at: https://doi.org/10.1371/journal.pone.0108589.en_US
dc.description.abstractObjective: To assess the prognostic and diagnostic value of whole blood impedance aggregometry in patients with sepsis and SIRS and to compare with whole blood parameters (platelet count, haemoglobin, haematocrit and white cell count). Methods: We performed an observational, prospective study in the acute setting. Platelet function was determined using whole blood impedance aggregometry (multiplate) on admission to the Emergency Department or Intensive Care Unit and at 6 and 24 hours post admission. Platelet count, haemoglobin, haematocrit and white cell count were also determined. Results: 106 adult patients that met SIRS and sepsis criteria were included. Platelet aggregation was significantly reduced in patients with severe sepsis/septic shock when compared to SIRS/uncomplicated sepsis (ADP: 90.7±37.6 vs 61.4±40.6; p<0.001, Arachadonic Acid 99.9±48.3 vs 66.3±50.2; p = 0.001, Collagen 102.6±33.0 vs 79.1±38.8; p = 0.001; SD ± mean)). Furthermore platelet aggregation was significantly reduced in the 28 day mortality group when compared with the survival group (Arachadonic Acid 58.8±47.7 vs 91.1±50.9; p<0.05, Collagen 36.6±36.6 vs 98.0±35.1; p = 0.001; SD ± mean)). However haemoglobin, haematocrit and platelet count were more effective at distinguishing between subgroups and were equally effective indicators of prognosis. Significant positive correlations were observed between whole blood impedance aggregometry and platelet count (ADP 0.588 p<0.0001, Arachadonic Acid 0.611 p<0.0001, Collagen 0.599 p<0.0001 (Pearson correlation)). Conclusions: Reduced platelet aggregometry responses were not only significantly associated with morbidity and mortality in sepsis and SIRS patients, but also correlated with the different pathological groups. Whole blood aggregometry significantly correlated with platelet count, however, when we adjust for the different groups we investigated, the effect of platelet count appears to be non-significant.en_US
dc.description.sponsorshipThis work is part-funded by the European Social Fund (ESF) through the European Union's Convergence programme administered by the Welsh Government.en_US
dc.language.isoenen_US
dc.publisherPLoSen_US
dc.relation.ispartofseriesPLoS ONE;
dc.titleThe Role of Whole Blood Impedance Aggregometry and Its Utilisation in the Diagnosis and Prognosis of Patients with Systemic Inflammatory Response Syndrome and Sepsis in Acute Critical Illnessen_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0108589
dcterms.dateAccepted2014-08-22
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.licenseref.startdate2019-11-25
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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