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dc.contributor.authorBusch, Stephen
dc.contributor.authorvan Diepen, Sean
dc.contributor.authorSteele, Andrew
dc.contributor.authorMeah, Victoria L.
dc.contributor.authorSimpson, Lydia
dc.contributor.authorFigueroa-Mujica, Romulo
dc.contributor.authorVizcardo Galindo, Gustavo
dc.contributor.authorVillafuerte, Francisco C.
dc.contributor.authorTymko, Mike M.
dc.contributor.authorAinslie, Philip N.
dc.contributor.authorMoore, Jonathan
dc.contributor.authorStembridge, Mike
dc.contributor.authorSteinback, Craig
dc.date.accessioned2020-01-07T12:02:33Z
dc.date.available2020-01-07T12:02:33Z
dc.date.issued2020-01-22
dc.identifier.citationBusch, S., van Diepen, S., Steele,A., Meah, V., Simpson, L., Figueroa-Mujica, R., Vizcardo Galindo, G., Villafuerte, F., Tymko, M., Ainslie, P., Moore, J., Stembridge, M. and Steinback, C.(2019) 'Global REACH: Assessment of brady-arrhythmias in Andeans and Lowlanders during apnea at 4330m', Frontiers in Physiology, doi: 10.3389/fphys.2019.01603en_US
dc.identifier.issn1664-042X
dc.identifier.urihttp://hdl.handle.net/10369/10881
dc.descriptionArticle published in Frontiers in Physiology on 22 January 2020, available open access at: https://www.frontiersin.org/articles/10.3389/fphys.2019.01603/abstracten_US
dc.description.abstractBACKGROUND: Ascent to altitude increases the prevalence of arrhythmogenesis in low-altitude dwelling populations (Lowlanders). High altitude populations (ie. Nepalese Sherpa) may have arrhythmias resistant adaptations that prevent arrhythmogenesis at altitude, though this has not been documented in other High altitude groups, including those diagnosed with chronic mountain sickness (CMS). We investigated whether healthy (CMS-) and CMS afflicted (CMS+) Andeans exhibit cardiac arrhythmias under acute apneic stress at altitude. METHODS AND RESULTS: Electrocardiograms (lead II) were collected in CMS- (N=9), CMS+ (N=8), and Lowlanders (N= 13) following several days at 4330m (Cerro de Pasco, Peru). ECG rhythm and HR were assessed at both rest and during maximal volitional apnea (End-Expiratory [EXP]). Both CMS- and CMS+ had similar basal HR (69 ± 8 beats/min vs. 62 ± 11 beats/min), while basal HR was higher in Lowlanders (77 ± 18 beats/min; P<0.05 versus CMS+). Apnea elicited significant bradycardia (nadir -32 ± 15 beats/min; P<0.01) and the development of arrhythmias in 8/13 Lowlanders (junctional rhythm, 3° atrio-venticular block, sinus pause). HR was preserved was prior to volitional breakpoint in both CMS- (nadir -6 ± 1 beat/min) and CMS+ (1 ±12 beats/min), with 2/17 Andeans developing arrhythmias ( 1 CMS+ and 1 CMS-; both Premature Atrial Contraction) prior to breakpoint. CONCLUSIONS: Andeans showed an absence of arrhythmias and preserved HR response to volitional apnea at altitude, demonstrating that potential cardio-resistant adaptations to arrhythmogenesis exist across permanent HA populations. Acclimatized Lowlanders have further demonstrated an increased prevalence of arrhythmias at altitude.en_US
dc.language.isoenen_US
dc.publisherFrontiers Mediaen_US
dc.relation.ispartofseriesFrontiers in Physiology;
dc.subjecthypoxiaen_US
dc.subjectAndeanen_US
dc.subjectarrhythmiaen_US
dc.subjectchronic mountain sicknessen_US
dc.subjectElectrophysiologyen_US
dc.subjecthigh altitude physiologyen_US
dc.subjectCardiacen_US
dc.titleGlobal REACH: Assessment of brady-arrhythmias in Andeans and Lowlanders during apnea at 4330men_US
dc.typeArticleen_US
dc.identifier.doihttps://doi.org/10.3389/fphys.2019.01603
dcterms.dateAccepted2019-12-20
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionAMen_US
rioxxterms.licenseref.urihttp://creativecommons.org/licenses/by/4.0/en_US
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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