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dc.contributor.authorAli, Danish
dc.contributor.authorCallan, Nualla
dc.contributor.authorEnnis, Stuart
dc.contributor.authorPowell, Richard
dc.contributor.authorMcGuire, Scott
dc.contributor.authorMcGregor, Gordon
dc.contributor.authorWeickert, Martin
dc.contributor.authorMiller, Michelle A.
dc.contributor.authorCappuccio, Francesco P.
dc.contributor.authorBanerjee, Prithwish
dc.date.accessioned2020-01-15T10:40:19Z
dc.date.available2020-01-15T10:40:19Z
dc.date.issued2019-11-19
dc.identifier.citationAli, D., Callan, N., Ennis, S., Powell, R., McGuire, S., McGregor, G., Weickert, M.O., Miller, M.A., Cappuccio, F.P. and Banerjee, P. (2019) 'Heart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and design', BMJ Open, 9(11). DOI: 10.1136/bmjopen-2018-027984.en_US
dc.identifier.issn2044-6055
dc.identifier.urihttp://hdl.handle.net/10369/10891
dc.descriptionArticle published in BMJ Open on 19 November 2019, available open access at: http://dx.doi.org/10.1136/bmjopen-2018-027984.en_US
dc.description.abstractAims: There has been a paradigm shift proposing that comorbidities are a major contributor towards the heart failure with preserved ejection fraction (HFpEF) syndrome. Furthermore, HFpEF patients have abnormal macrovascular and microvascular function, which may significantly contribute towards altered ventricular-vascular coupling in these patients. The IDENTIFY-HF study will investigate whether gradually increased arterial stiffness (in addition to ageing) as a result of increasing common comorbidities, such as hypertension and diabetes, is associated with HFpEF. Methods and analysis: In our observational study, arterial compliance and microvascular function will be assessed in five groups (Groups A to E) of age, sex and body mass index matched subjects (age ≥70 years in all groups): Group A; normal healthy volunteers without major comorbidities such as hypertension and diabetes mellitus (control). Group B; patients with hypertension without diabetes mellitus or heart failure (HF). Group C; patients with hypertension and diabetes mellitus without HF. Group D; patients with HFpEF. Group E; patients with heart failure and reduced ejection fraction (parallel group). Vascular function and arterial compliance will be assessed using pulse wave velocity, as the primary outcome measure. Further outcome measures include cutaneous laser Doppler flowmetry as a measure of endothelial function, transthoracic echocardiography and exercise tolerance measures. Biomarkers include NT-proBNP, high-sensitivity troponin T, as well as serum galectin-3 as a marker of fibrosis. Ethics and dissemination: The study was approved by the regional research ethics committee (REC), West Midland and Black Country 17/WM/0039, UK, and permission to conduct the study in the hospital was also obtained from the RDI, UHCW NHS Trust. The results will be published in peer-reviewed journals and presented in local, national and international medical society meetings. Trial registration number: NCT03186833en_US
dc.description.sponsorshipResearch grant from the West Midlands Clinical Research Network, National Institute of Health Research, UK. The study is sponsored by the Research, Development & Innovation department of the University Hospitals Coventry & Warwickshire NHS Trust (RDI, UHCW), UK.en_US
dc.language.isoenen_US
dc.publisherBMJ Publishing Groupen_US
dc.relation.ispartofseriesBMJ Open;
dc.titleHeart failure with preserved ejection fraction (HFpEF) pathophysiology study (IDENTIFY-HF): does increased arterial stiffness associate with HFpEF, in addition to ageing and vascular effects of comorbidities? Rationale and designen_US
dc.typeArticleen_US
dc.identifier.doihttp://dx.doi.org/10.1136/bmjopen-2018-027984
dcterms.dateAccepted2019-09-24
rioxxterms.funderCardiff Metropolitan Universityen_US
rioxxterms.identifier.projectCardiff Metropolian (Internal)en_US
rioxxterms.versionVoRen_US
rioxxterms.licenseref.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/en_US
rioxxterms.licenseref.startdate2020-01-15
rioxxterms.funder.project37baf166-7129-4cd4-b6a1-507454d1372een_US


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