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dc.contributor.authorSimpson, Lydia
dc.contributor.authorMeah, Victoria L.
dc.contributor.authorSteele, Andrew
dc.contributor.authorThapamagar, Suman
dc.contributor.authorGasho, Chris
dc.contributor.authorAnholm, James
dc.contributor.authorDrane, Aimee L.
dc.contributor.authorDawkins, Tony
dc.contributor.authorBusch, Stephen
dc.contributor.authorOliver, Samuel
dc.contributor.authorLawley, Justin
dc.contributor.authorTymko, Mike
dc.contributor.authorAinslie, Philip
dc.contributor.authorSteinback, Craig
dc.contributor.authorStembridge, Mike
dc.contributor.authorMoore, Jonathan
dc.date.accessioned2020-01-24T13:45:19Z
dc.date.available2020-01-24T13:45:19Z
dc.date.issued2020-01-24
dc.identifierhttps://repository.cardiffmet.ac.uk/bitstream/id/44563/Simpson,%20Stembridge,%20Drane,%20dawkins%20J%20Physiol%20iNO%20paper.pdf
dc.identifier.citationSimpson, L.L., Meah, V.L., Steele, A., Thapamagar, S., Gasho, C., Anholm, J.D., Drane, A.L., Dawkins, T.G., Busch, S.A., Oliver, S.J. and Lawley, J.S. (2020) 'Evidence for a physiological role of pulmonary arterial baroreceptors in sympathetic neural activation in healthy humans', Journal of Physiology.
dc.identifier.issn0022-3751
dc.identifier.issn1469-7793
dc.identifier.urihttp://hdl.handle.net/10369/10902
dc.descriptionArticle published in Journal of Physiology on 24 January 2020, available at: https://doi.org/10.1113/JP278731.en_US
dc.description.abstractIn animal models, distension of baroreceptors located in the pulmonary artery induces a reflex increase in sympathetic outflow; however, this has not been examined in humans. Therefore, we investigated whether reductions in pulmonary arterial pressure influenced sympathetic outflow and baroreflex control of muscle sympathetic nerve activity (MSNA). Healthy lowlanders (n=13; 5 females) were studied 4-8 days following arrival at high-altitude (4383m; Cerro de Pasco, Peru), a setting that increases both pulmonary arterial pressure and sympathetic outflow. MSNA (microneurography) and blood pressure (BP; photoplethysmography) were measured continuously during 1) ambient air breathing (Amb) and 2) a six-minute inhalation of the vasodilator nitric oxide (iNO; 40ppm in 21% O2), to selectively lower pulmonary arterial pressure. A modified Oxford test was performed under both conditions. Pulmonary artery systolic pressure (PASP) was determined using Doppler echocardiography. iNO reduced PASP (24±3 vs 32±5 mmHg; P < 0.001) compared to Amb, without changing heart rate (P= 0.6) or vascular-sympathetic baroreflex gain (P = 0.85). In conclusion, unloading of pulmonary arterial baroreceptors reduced basal sympathetic outflow to the skeletal muscle vasculature and reset vascular-sympathetic baroreflex control of MSNA downward and leftward in healthy humans at high-altitude. These data suggest the existence of a lesser-known reflex input involved in sympathetic activation in humans.en_US
dc.description.sponsorshipCanadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology): Craig D Steinback, RGPIN 06637; Heart and Stroke Foundation of Canada - Joint Alberta and new investigator award: Craig D Steinback, HSCF NNIA; Canadian Research Chair in Cerebrovascular Physiology: Philip N Ainslie, 950-230970; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada (NSERC Canadian Network for Research and Innovation in Machining Technology): Philip N Ainslie, 20150821-01en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofseriesJournal of Physiology;
dc.subjectsympathetic nervous systemen_US
dc.subjectpulmonary baroreceptorsen_US
dc.subjecthigh-altitudeen_US
dc.subjecthypoxiaen_US
dc.subjectmuscle sympathetic nerve activityen_US
dc.subjectbaroreflexen_US
dc.titleEvidence for a physiological role of pulmonary arterial baroreceptors in sympathetic neural activation in healthy humansen_US
dc.typeArticleen_US
dc.typeacceptedVersion
dcterms.dateAccepted2020-01-20
rioxxterms.versionAMen_US
rioxxterms.versionofrecordhttps://doi.org/10.1113/JP278731
rioxxterms.licenseref.urihttp://www.rioxx.net/licenses/all-rights-reserveden_US
rioxxterms.publicationdate2020-01-24
dc.date.refFCD2020-01-24
rioxxterms.freetoread.startdate2021-01-24


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