Iliocaval venous obstruction, cardiac preload reserve, and exercise limitation
Stöhr, Eric J.
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Cardiac output during exercise increases by as much as five-fold in the untrained man, and by as much as eight-fold in the elite athlete. Increasing venous return is a critical but much overlooked component of the physiological response to exercise. Cardiac disorders such as constrictive pericarditis, restrictive cardiomyopathy and pulmonary hypertension are recognised to impair preload and cause exercise limitation, however the effects of peripheral venous obstruction on cardiac function have not been well described. This manuscript will discuss how obstruction of the iliocaval venous outflow can lead to impairment in exercise tolerance; how such obstructions may be diagnosed, the potential implications of chronic obstructions on sympathetic nervous system activation, and relevance of venous compression syndromes in heart failure with preserved ejection fraction.
Journal of Cardiovascular Translational Research;
Morris, R., Sobotka, P., Balmforth, P., Stöhr, E.J., McDonnell, B., Spencer, D., O'Sullivan, G. and Black, S. (2020) 'Iliocaval venous obstruction, cardiac preload reserve, and exercise limitation', Journal of Cardiovascular Translational Research. DOI: 10.1007/s12265-020-09963-w
Article published in Journal of Cardiovascular Translational Research on 10 February 2020 (online), available open access at: https://doi.org/10.1007/s12265-020-09963-w.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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