Evaluation of relationships between results of electrocardiography and echocardiography in 341 chimpanzees (Pan troglodytes)
Drane, Aimee L.
van Bolhuis, Hester
American Veterinary Medical Association
MetadataShow full item record
Objective – to examine potential relationship(s) between electrocardiographic characteristics and measures of cardiac structure in chimpanzees (Pan troglodytes). Animals – 341 chimpanzees, 175 males and 166 females. Procedures – During routine health examinations, 341 chimpanzees from five sanctuaries and two zoological collections underwent a 12-lead electrocardiogram (ECG) and transthoracic echocardiogram assessment. Relationships between multiple ECG characteristics and echocardiographic measures, of atrial areas, left ventricular internal cavity dimension and wall thicknesses were first explored using correlational analysis, then multiple linear regression analyses were used to create hierarchical models to predict cardiac structure from the ECG. Results – Significant correlations between ECG characteristics and echocardiographic measures of cardiac morphology were observed (r2 range: -0.231 – 0.310). P wave duration and amplitude in lead II had the strongest correlations to atrial areas. Sokolow-Lyon criteria, QRS duration, R wave in V6 and II demonstrated the strongest correlations with mean left ventricular wall thickness, while the Sokolow-Lyon criteria, QRS duration, S wave in V2 and V1 had the strongest correlations with the internal dimension of the left ventricle. Despite these significant correlations the predictive models generated only accounted for 17,7,11,8% of the variance in right and left atrial areas, left ventricular (LV) wall thicknesses and LV internal dimension, respectively. Conclusions and Clinical Relevance – This study has shown significant relationships exist between the ECG and cardiac morphology in chimpanzees. Further work is required to examine whether the prediction models generated can be modified to improve their clinical utility.
American Journal of Veterinary Research;
Article published in American Journal of Veterinary Research on 22 May 2020, available at: https://doi.org/10.2460/ajvr.81.6.488.
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
- Import 
Showing items related by title, author, subject and abstract.
The Influence of Age and Sex on Measures of Body Size in Captive Chimpanzees (Pan troglodytes) Cared for in African Wildlife Sanctuaries and Zoological Collections Curry, Bryony (Cardiff Metropolitan University, 2020)Introduction: The typical growth pattern of chimpanzees (Pan troglodytes) has largely been derived from captive research populations, as methodological and ethical challenges limit assessment of their wild counterparts. ...
Electrocardiogram reference intervals for clinically normal wild-born chimpanzees (Pan troglodytes) Atencia, Rebeca; Revuelta, Luis; Somauroo, John; Shave, Rob (American Veterinary Medical Association, 2015-08)OBJECTIVE To generate reference intervals for ECG variables in clinically normal chimpanzees (Pan troglodytes). ANIMALS 100 clinically normal (51 young [< 10 years old] and 49 adult [≥ 10 years old]) wild-born ...
Cardiac structure and function characterized across age groups and between sexes in healthy wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries Drane, Aimee L.; Atencia, Rebeca; Cooper, Stephen-Mark; Rodriguez, Pablo; Sanchez, Carlos; Simcox, Sarah; Feltrer, Yedra; Peck, Bruce; Eng, Jaclyn; Moittie, Sophie; Unwin, Steve; Howatson, Glyn; Oxborough, David; Stembridge, Mike; Shave, Rob (American Veterinary Medical Association, 2019-06)Objective: To comprehensively characterize cardiac structure and function, from infancy to adulthood, in male and female wild-born captive chimpanzees (Pan troglodytes) living in sanctuaries. Animals: 290 wild-born captive ...