Evaluation of relationships between results of electrocardiography and echocardiography in 341 chimpanzees (Pan troglodytes)

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Author
Drane, Aimee L.
Atencia, Rebeca
Cooper, Stephen-Mark
Feltrer, Yedra
Calvi, Thalita
Strike, Tai
Palmer, Christopher
Simcox, Sarah
Rodriguez, Pablo
Sanchez, Carlos
van Bolhuis, Hester
Peck, Bruce
Eng, Jaclyn
Moittie, Sophie
Unwin, Steve
Howatson, Glyn
Oxborough, David
Stembridge, Mike
Shave, Rob
Date
2020-05-22Acceptance date
2020-01-10
Type
Article
Publisher
American Veterinary Medical Association
ISSN
1943-5681
Embargoed until
2100-01-01
Metadata
Show full item recordAbstract
Objective – to examine potential relationship(s) between electrocardiographic characteristics
and measures of cardiac structure in chimpanzees (Pan troglodytes).
Animals – 341 chimpanzees, 175 males and 166 females.
Procedures – During routine health examinations, 341 chimpanzees from five sanctuaries
and two zoological collections underwent a 12-lead electrocardiogram (ECG) and
transthoracic echocardiogram assessment. Relationships between multiple ECG
characteristics and echocardiographic measures, of atrial areas, left ventricular internal cavity
dimension and wall thicknesses were first explored using correlational analysis, then multiple
linear regression analyses were used to create hierarchical models to predict cardiac structure
from the ECG.
Results – Significant correlations between ECG characteristics and echocardiographic
measures of cardiac morphology were observed (r2 range: -0.231 – 0.310). P wave duration
and amplitude in lead II had the strongest correlations to atrial areas. Sokolow-Lyon criteria,
QRS duration, R wave in V6 and II demonstrated the strongest correlations with mean left
ventricular wall thickness, while the Sokolow-Lyon criteria, QRS duration, S wave in V2 and
V1 had the strongest correlations with the internal dimension of the left ventricle. Despite
these significant correlations the predictive models generated only accounted for 17,7,11,8%
of the variance in right and left atrial areas, left ventricular (LV) wall thicknesses and LV
internal dimension, respectively.
Conclusions and Clinical Relevance – This study has shown significant relationships exist
between the ECG and cardiac morphology in chimpanzees. Further work is required to
examine whether the prediction models generated can be modified to improve their clinical
utility.
Journal/conference proceeding
American Journal of Veterinary Research;
Description
Article published in American Journal of Veterinary Research on 22 May 2020, available at: https://doi.org/10.2460/ajvr.81.6.488.
Closed deposit
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
- Sport Research Groups [1084]
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