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Association between Aortic Stiffness and Cerebral Pulsatility is Modestly Influenced by Augmentation Index

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Author
Pearson, James
Watkeys, Laura
Coulson, James
Schlader, Zachary
Crandall, Craig
Cockcroft, John R.
McEniery, Carmel
McDonnell, Barry
Date
2019-12-24
Acceptance date
2019-12-01
Type
Article
Publisher
Atlantis Press
ISSN
1876-4401 (online)
1872-9312
Metadata
Show full item record
Abstract
Central Pulse Pressure (CPP) and Aortic Pulse Wave Velocity (aPWV) share a positive relationship with cerebral pulsatility and are associated with cerebrovascular disorders including stroke. Our aim was to examine the influence of Augmentation Index (AIx) upon this relationship, first by using a cross sectional design across a wide range of CPP and aPWV in healthy individuals and second, following administration of Glyceryl Trinitrate (GTN) to acutely change AIx. We measured CPP, aPWV, AIx and Middle Cerebral Artery Pulsatility Index (MCAPI) in 99 healthy individuals (54 females). In all individuals, after accounting for the effect of age and gender, MCAPI shared an independent inverse relationship with AIx (β = −0.515, R2 = 0.109; p = 0.001), and a positive relationship with CPP (β = 0.570, R2 = 0.093; p = 0.003) but not aPWV (p > 0.05). GTN was administered to 25 of these participants (14 females). Following GTN, AIx75 decreased in all participants relative to baseline (12 ± 19 to 5 ± 16%; p = 0.0001). In the 20 min following GTN administration, CPP shared a positive relationship with MCAPI (β = 0.305, R2 = 0.042; p = 0.002) while AIx, adjusted for heart rate (AIx75), shared an inverse relationship with MCAPI (β = −0.320, R2 = 0.019; p = 0.031). These findings indicate that the positive relationship between CPP and MCAPI may be somewhat modified by AIx. This suggests that an increased AIx may weakly attenuate increases in MCAPI that are associated with aortic stiffening in a healthy population at rest, but also following acute reductions in AIx75 after administration of GTN.
Journal/conference proceeding
Artery Research;
Citation
Pearson, J., Watkeys, L.J., Coulson, J.M., Schlader, Z.J., Crandall, C.G., Cockcroft, J.R., McEniery, C.M. and McDonnell, B.J. (2019) 'Association between Aortic Stiffness and Cerebral Pulsatility is Modestly Influenced by Augmentation Index', Artery Research. https://dx.doi.org/10.2991/artres.k.191212.001
URI
http://hdl.handle.net/10369/10933
DOI
https://dx.doi.org/10.2991/artres.k.191212.001
Description
Article published in Artery Research, available open access at https://dx.doi.org/10.2991/artres.k.191212.001
Rights
http://creativecommons.org/licenses/by-nc/4.0/
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
Collections
  • Cardiovascular Health and Ageing [156]

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