Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?

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Author
Erusalimsky, Jorge
Date
2020-02-13Acceptance date
2020-02-10
Type
Article
Publisher
Elsevier
ISSN
1873-4596
Metadata
Show full item recordAbstract
Telomeres are higher order structures that cap and protect chromosome ends. Telomeric DNA naturally shortens during somatic cell division and as a result of oxidative stress. Excessive shortening disrupts the integrity of the telomere, causing cellular senescence, one of the hallmarks of organismal ageing. The accumulation of senescent cells with ageing contributes to the loss of tissue homeostasis and the development of age-related pathologies. Hence, counteracting telomere shortening may be one relevant approach to develop strategies for healthier ageing. In this review I present the case for the existence of a link between oxidative stress, accelerated telomere shortening and cellular senescence. I also examine findings from human observational studies exploring associations between telomere length and oxidative stress-related parameters. Finally, I discuss results from randomised control trials testing the impact of non-pharmacological lifestyle interventions on the maintenance of telomere length, considering the potential mechanisms that might be involved.
Journal/conference proceeding
Free Radical Biology and Medicine;
Citation
Erusalimsky, J.D. (2020) 'Oxidative stress, telomeres and cellular senescence: What non-drug interventions might break the link?', Free Radical Biology and Medicine. DOI: 10.1016/j.freeradbiomed.2020.02.008.
Description
Article published in Free Radical Biology and Medicine on 13 February 2020 (online), available at: https://doi.org/10.1016/j.freeradbiomed.2020.02.008.
Sponsorship
Cardiff Metropolitan University (Grant ID: Cardiff Metropolian (Internal))
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